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Literature summary for 3.5.1.88 extracted from

  • Hu, Y.J.; Wie, Y.; Zhou, Y.; Rajagopalan, P.T.R.; Pei, D.
    Determination of substrate specificity for peptide deformylase through the screening of a combinatorial peptide library (1999), Biochemistry, 38, 643-650.
    View publication on PubMed
Search for more literature for 3.5.1.88

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.49
-
 N-formyl-Phe-Tyr-Phe-His-beta-alanine-Arg
-
 Escherichia coli
0.95
-
 N-formyl-Met-Ala-Phe-Tyr-beta-Ala-Arg
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-formyloxycaproylleucyl-p-nitroanilide + H2O esterase activity, 10fold lower activity compared to N-formyl-Met-Leu-p-nitroanilide Escherichia coli ?
-
 ?
N-(alpha-difluoroacetyl)-Met-Leu-p-nitroanilide + H2O
-
 Escherichia coli difluoroacetic acid + Met-Leu-p-nitroanilide
-
 ?
N-(alpha-fluoroacetyl)-Met-Leu-p-nitroanilide + H2O
-
 Escherichia coli fluoroacetic acid + Met-Leu-p-nitroanilide
-
 ?
N-formyl-Met-Ala-Phe-Tyr-beta-Ala-Arg + H2O
-
 Escherichia coli formate + Met-Ala-Phe-Tyr-beta-Ala-Arg
-
 ?
N-formyl-Met-Leu-p-nitroanilide + H2O
-
 Escherichia coli formate + Met-Leu-p-nitroanilide
-
 ?
N-formyl-Met-Xaa-Xbb-Tyr + H2O consesus sequence for best substrates, Xaa: any amino acid except for Asp and Glu, Xbb: Lys, Arg, Tyr or Phe Escherichia coli formate + Met-Xaa-Xbb-Tyr
-
 ?
N-formyl-Phe-Tyr-Phe + H2O only N-terminal Phe can replace Met Escherichia coli formate + Phe-Tyr-Phe
-
 ?
N-formyl-Phe-Tyr-Phe-His-beta-Ala-Arg + H2O
-
 Escherichia coli formate + Phe-Tyr-Phe-His-beta-Ala-Arg
-
 ?
N-formyl-Phe-Tyr-Tyr + H2O only N-terminal Phe can replace Met Escherichia coli formate + Phe-Tyr-Tyr
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
204
-
 N-formyl-Phe-Tyr-Phe-His-beta-Ala-Arg
-
 Escherichia coli
1030
-
 N-formyl-Met-Ala-Phe-Tyr-beta-Ala-Arg
-
 Escherichia coli