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Literature summary for 3.5.1.5 extracted from
- Some monohydroxy tetradecanoic acid isomers as novel urease and elastase inhibitors and as new antioxidants (2014), Appl. Biochem. Biotechnol., 172, 1358-1364.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | 3-,6-,7-,9-,12-monohydroxy tetradecanoic acid isomers can be used in agriculture, pharmacy and cosmetic industries due to their excellent antielastase, antiurease and antioxidant activities. Hydroxy fatty acids can be urease inhibitors and anti-Helicobacter pylori agents due to their antiurease activity | Helicobacter pylori |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 12-hydroxytetradecanoic acid | 48.47% inhibition at 100 ng/ml | Helicobacter pylori |  |
| 3-hydroxytetradecanoic acid | 49.20% inhibition at 100 ng/ml | Helicobacter pylori | |
| 6-hydroxytetradecanoic acid | 59.01% inhibition at 100 ng/ml | Helicobacter pylori | |
| 7-hydroxytetradecanoic acid | 53.43% inhibition at 100 ng/ml | Helicobacter pylori | |
| 9-hydroxytetradecanoic acid | 52.97% inhibition at 100 ng/ml | Helicobacter pylori | |
| additional information | evaluation of 3-,6-,7-,9-,12-monohydroxy tetradecanoic acids as enzyme inhibitors in agriculture, overview | Helicobacter pylori |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| urea + H2O | Helicobacter pylori | - |
CO2 + 2 NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| urea + H2O | - |
Helicobacter pylori | CO2 + 2 NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| urea amido hydrolase | - |
Helicobacter pylori |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
pH and temperature not specified in the publication | Helicobacter pylori | 6-hydroxytetradecanoic acid | |
| 0.083 | - |
pH and temperature not specified in the publication | Helicobacter pylori | 9-hydroxytetradecanoic acid | |
| 0.09 | - |
pH and temperature not specified in the publication | Helicobacter pylori | 7-hydroxytetradecanoic acid | |
| 0.1 | - |
pH and temperature not specified in the publication | Helicobacter pylori | 3-hydroxytetradecanoic acid | |
| 0.101 | - |
pH and temperature not specified in the publication | Helicobacter pylori | 12-hydroxytetradecanoic acid | |
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