Literature summary for 3.5.1.5 extracted from

Xiao, Z.P.; Shi, D.H.; Li, H.Q.; Zhang, L.N.; Xu, C.; Zhu, H.L.
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease (2007), Bioorg. Med. Chem., 15, 3703-3710.

Search for more literature for 3.5.1.5

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone	0.4 mg/ml, 16% inhibition	Helicobacter pylori
1-(3,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone	0.4 mg/ml, 39% inhibition	Helicobacter pylori
2,3,4,4'-tetrahydroxydeoxybenzoin	0.4 mg/ml, 51% inhibition	Helicobacter pylori
2,3,4-trihydroxy-4'-methoxydeoxybenzoin	0.4 mg/ml, 44% inhibition	Helicobacter pylori
2,4,4',6-tetrahydroxy-3-methoxyphenyldeoxybenzoin	0.4 mg/ml, 17% inhibition	Helicobacter pylori
2,4-dihydroxy-4'-methoxydeoxybenzoin	0.4 mg/ml, 14% inhibition	Helicobacter pylori
2,4-dihydroxyacetophenone	0.4 mg/ml, 14% inhibition	Helicobacter pylori
3,4-Dihydroxyacetophenone	0.4 mg/ml, 41% inhibition	Helicobacter pylori
4-(p-hydroxyphenethyl)pyrogallol	0.4 mg/ml, 94.5% inhibition	Helicobacter pylori
6-(1-hydroxy-2-(4-methoxyphenyl)ethyl)-2,3-dimethoxyphenol	0.4 mg/ml, 42% inhibition	Helicobacter pylori
7,8,4'-trihydroxyisoflavone	0.4 mg/ml, 81.7% inhibition	Helicobacter pylori
gallacetophenone	0.4 mg/ml, 38% inhibition	Helicobacter pylori
psi-tectorigenin	0.4 mg/ml, 36% inhibition	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
urea + H2O	-	Helicobacter pylori	CO2 + NH3	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.03	-	-	Helicobacter pylori	4-(p-hydroxyphenethyl)pyrogallol
0.14	-	-	Helicobacter pylori	7,8,4'-trihydroxyisoflavone

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Release 2023.1 (January 2023)