Cloned (Comment) | Organism |
---|---|
recombinant expression in Escherichia coli strain BL21(DE3) | Mycoplana ramosa |
Protein Variants | Comment | Organism |
---|---|---|
H159A | catalytically inactive mutant | Mycoplana ramosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-[(3-aminopropyl)amino]pentane-1-thiol | - |
Mycoplana ramosa | |
5-[(3-aminopropyl)amino]pentylboronic acid | - |
Mycoplana ramosa | |
6-[(3-aminopropyl)amino]-N-hydroxyhexanamide | - |
Mycoplana ramosa | |
6-[(3-aminopropyl)amino]hexanoic acid | - |
Mycoplana ramosa | |
7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one | - |
Mycoplana ramosa | |
7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one | - |
Mycoplana ramosa | |
7-[(3-aminopropyl)amino]heptan-2-one | - |
Mycoplana ramosa | |
additional information | design, synthesis, and evaluation of N8-acetylspermidine analogues bearing different zinc binding groups as potential inhibitors of the enzyme, overview. Most of the synthesized compounds exhibit modest potency, with IC50 values in the mid-micromolar range, but compounds bearing hydroxamate or trifluoromethylketone zinc binding groups exhibit enhanced inhibitory potency in the mid-nanomolar range. Three compounds exhibit very poor inhibitory potency against th enzyme, 6-[(3-aminopropyl)amino]hexanoic acid, S-{5-[(3-aminopropyl)amino]pentyl} thioacetate, and N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine dihydrochloride | Mycoplana ramosa | |
N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-hydroxyhexanamide | - |
Mycoplana ramosa | |
N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-methoxy-N-methylhexanamide | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentan-1-ol | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentane-1-thiol | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanal | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanoic acid | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-ol | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-ol | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-one | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-ol | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one | - |
Mycoplana ramosa | |
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]heptan-2-one | - |
Mycoplana ramosa | |
N1,N3-bis(tert-butoxycarbonyl)-N1-(5-bromopentyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
N1,N3-bis(tert-butoxycarbonyl)-N1-(hept-6-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
N1,N3-bis(tert-butoxycarbonyl)-N1-(pent-4-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylthio)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(oxiran-2-yl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
N1-(hept-6-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
N1-(pent-4-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
S-{5-[(3-aminopropyl)amino]pentyl} thioacetate | - |
Mycoplana ramosa | |
S-{7-[(3-aminopropyl)amino]-2-oxoheptyl} ethanethioate | - |
Mycoplana ramosa | |
S-{N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentyl} thioacetate | - |
Mycoplana ramosa | |
S-{N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-2-oxoheptyl}thioacetate | - |
Mycoplana ramosa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Mycoplana ramosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mycoplana ramosa | the bacterial enzyme from Mycoplana ramosa has broader substrate specificity in comparison with mammalian enzyme. Its substrates include both small and large acetylpolyamines such as acetylputrescine, acetylcadaverine, N1- and N8-acetylspermidine, and N1-acetylspermine | ? | - |
? | |
N1-acetylspermidine + H2O | Mycoplana ramosa | - |
acetate + spermidine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycoplana ramosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcadaverine + H2O | - |
Mycoplana ramosa | acetate + cadaverine | - |
? | |
acetylputrescine + H2O | - |
Mycoplana ramosa | acetate + putrescine | - |
? | |
additional information | the bacterial enzyme from Mycoplana ramosa has broader substrate specificity in comparison with mammalian enzyme. Its substrates include both small and large acetylpolyamines such as acetylputrescine, acetylcadaverine, N1- and N8-acetylspermidine, and N1-acetylspermine | Mycoplana ramosa | ? | - |
? | |
additional information | usage of the commercially available Fluor-de-Lys deacetylase fluorogenic substrate fir enzyme activity assays | Mycoplana ramosa | ? | - |
? | |
N1-acetylspermidine + H2O | - |
Mycoplana ramosa | acetate + spermidine | - |
? | |
N1-acetylspermine + H2O | - |
Mycoplana ramosa | acetate + spermine | - |
? | |
N8-acetylspermidine + H2O | - |
Mycoplana ramosa | acetate + spermidine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Mycoplana ramosa |
Synonyms | Comment | Organism |
---|---|---|
acetylpolyamine amidohydrolase | - |
Mycoplana ramosa |
APAH | - |
Mycoplana ramosa |
N1-acetylspermidine deacetylase | - |
Mycoplana ramosa |
N8-acetylspermidine deacetylase | - |
Mycoplana ramosa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mycoplana ramosa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
assay at | Mycoplana ramosa |