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Literature summary for 3.5.1.23 extracted from

  • Monick, M.M.; Mallampalli, R.K.; Bradford, M.; McCoy, D.; Gross, T.J.; Flaherty, D.M.; Powers, L.S.; Cameron, K.; Kelly, S.; Merrill, A.H.; Hunninghake, G.W.
    Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity (2004), J. Immunol., 173, 123-135.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information blocking of acid ceramidase but not sphingosine kinase activity in alveolar macrophages leads to decreased ERK and Akt activity and induction of cell death, sphingosine and L-threo-dihydrosphingosine reverse the antisurvival effects of acid ceramidase inhibition in alveolar macrophages Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-oleoylethanolamine specific inhibition of acid ceramidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cooperative prosurvival activity by MAP kinases ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity, overview, blocking of acid ceramidase but not sphingosine kinase activity in alveolar macrophages leads to decreased ERK and Akt activity and induction of cell death, sphingosine and L-threo-dihydrosphingosine reverse the antisurvival effects of acid ceramidase inhibition in alveolar macrophages ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar macrophage high levels of acid ceramidase Homo sapiens
-
additional information quantitation of acid ceramidase mRNA, overview, little ceramidase protein or activity, or sphingosine, in monocytes Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
sphingolipid and cell survival analysis, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cooperative prosurvival activity by MAP kinases ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity, overview, blocking of acid ceramidase but not sphingosine kinase activity in alveolar macrophages leads to decreased ERK and Akt activity and induction of cell death, sphingosine and L-threo-dihydrosphingosine reverse the antisurvival effects of acid ceramidase inhibition in alveolar macrophages Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
acid ceramidase
-
Homo sapiens
neutral ceramidase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens