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Literature summary for 3.5.1.18 extracted from

  • Uda, N.R.; Creus, M.
    Selectivity of inhibition of N-succinyl-L,L-diaminopimelic acid desuccinylase in bacteria: the product of dapE-gene is not the target of L-captopril antimicrobial activity (2011), Bioinorg. Chem. Appl., 2011, 306465.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli XL1-Blue cells and in Salmonella enterica strain TN5911 Salmonella enterica

Inhibitors

Inhibitors Comment Organism Structure
L-captopril low-micromolar inhibitor, DapE is not the main target of L-captopril inhibition Salmonella enterica

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ the enzyme possesses a catalytic domain with a di-zinc active site Salmonella enterica

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41600
-
 2 * 41600, estimated from amino acid sequence Salmonella enterica
42000
-
 2 * 42000, SD-PAGE Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-succinyl-LL-2,6-diaminoheptanedioate + H2O Salmonella enterica i.e. N-succinyl-L,L-diaminopimelic acid succinate + LL-2,6-diaminoheptanedioate
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-LL-2,6-diaminoheptanedioate + H2O i.e. N-succinyl-L,L-diaminopimelic acid Salmonella enterica succinate + LL-2,6-diaminoheptanedioate
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 41600, estimated from amino acid sequence Salmonella enterica
homodimer 2 * 42000, SD-PAGE Salmonella enterica

Synonyms

Synonyms Comment Organism
DapE
-
 Salmonella enterica
N-succinyl-L,L-diaminopimelic acid desuccinylase
-
 Salmonella enterica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0018
-
 L-captopril pH and temperature not specified in the publication Salmonella enterica

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0033
-
 pH and temperature not specified in the publication Salmonella enterica L-captopril