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Literature summary for 3.5.1.16 extracted from

  • Hlavacek, J.; Picha, J.; Vanek, V.; Jiracek, J.; Slaninova, J.; Fucik, V.; Budesinsky, M.; Gilner, D.; Holz, R.C.
    Inhibitors of N(alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency (2010), Amino Acids, 38, 1155-1164.
    View publication on PubMed
Search for more literature for 3.5.1.16

Inhibitors

Inhibitors Comment Organism Structure
3-(ethylamino)piperidin-2-one
-
 Bacillus subtilis
additional information synthesis and inhibitory potencies of a series of Nalpha-acyl/alkyl and Nalpha-alkoxycarbonyl derivatives of D- and L-ornithinie, overview. Minimal inhibitory concentrations of inhibitors in bacteria growth inhibition studies, overview Bacillus subtilis
N2-(2,2-dimethylpropanoyl)-L-ornithine
-
 Bacillus subtilis
N2-(2-methylpropanoyl)-L-ornithine
-
 Bacillus subtilis
N2-(ethoxycarbonyl)-L-ornithine weak inhibition Bacillus subtilis
N2-(methoxycarbonyl)-L-ornithine
-
 Bacillus subtilis
N2-(propoxycarbonyl)-L-ornithine
-
 Bacillus subtilis
N2-(tert-butoxycarbonyl)-L-ornithine
-
 Bacillus subtilis
N2-(trifluoroacetyl)-L-ornithine weak inhibition Bacillus subtilis
N2-acetyl-D-ornithine weak inhibition Bacillus subtilis
N2-butanoyl-L-ornithine
-
 Bacillus subtilis
N2-chloroacetyl-L-ornithine
-
 Bacillus subtilis
N2-dichloroacetyl-L-ornithine
-
 Bacillus subtilis
N2-ethyl-L-ornithine
-
 Bacillus subtilis
N2-propanoyl-L-ornithine
-
 Bacillus subtilis
N2-trichloroacetyl-D-ornithine
-
 Bacillus subtilis
N2-trichloroacetyl-L-ornithine
-
 Bacillus subtilis
N2-[(propan-2-yloxy)carbonyl]-L-ornithine
-
 Bacillus subtilis
N2-[[(2-methylpentan-2-yl)oxy]carbonyl]-L-ornithine
-
 Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bacillus subtilis 168
-
-
-

Synonyms

Synonyms Comment Organism
ArgE
-
 Bacillus subtilis
N(alpha)-acetyl-L-ornithine deacetylase
-
 Bacillus subtilis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.085
-
 pH 7.5, 25°C Bacillus subtilis N2-chloroacetyl-L-ornithine
0.2
-
 pH 7.5, 25°C Bacillus subtilis N2-(trifluoroacetyl)-L-ornithine
0.25
-
 pH 7.5, 25°C Bacillus subtilis N2-(ethoxycarbonyl)-L-ornithine
0.32
-
 pH 7.5, 25°C Bacillus subtilis N2-trichloroacetyl-D-ornithine
0.34
-
 pH 7.5, 25°C Bacillus subtilis N2-dichloroacetyl-L-ornithine
0.41
-
 pH 7.5, 25°C Bacillus subtilis N2-acetyl-D-ornithine
0.42
-
 pH 7.5, 25°C Bacillus subtilis N2-butanoyl-L-ornithine
0.45
-
 pH 7.5, 25°C Bacillus subtilis N2-trichloroacetyl-L-ornithine
0.54
-
 pH 7.5, 25°C Bacillus subtilis N2-(tert-butoxycarbonyl)-L-ornithine
0.71
-
 pH 7.5, 25°C Bacillus subtilis N2-(propoxycarbonyl)-L-ornithine
0.76
-
 pH 7.5, 25°C Bacillus subtilis N2-propanoyl-L-ornithine
1.01
-
 pH 7.5, 25°C Bacillus subtilis N2-(methoxycarbonyl)-L-ornithine
1.16
-
 pH 7.5, 25°C Bacillus subtilis N2-[[(2-methylpentan-2-yl)oxy]carbonyl]-L-ornithine
1.21
-
 pH 7.5, 25°C Bacillus subtilis N2-(2-methylpropanoyl)-L-ornithine
1.4
-
 pH 7.5, 25°C Bacillus subtilis N2-[(propan-2-yloxy)carbonyl]-L-ornithine
2.5
-
 pH 7.5, 25°C Bacillus subtilis 3-(ethylamino)piperidin-2-one
2.7
-
 pH 7.5, 25°C Bacillus subtilis N2-ethyl-L-ornithine
5.4
-
 about, pH 7.5, 25°C Bacillus subtilis N2-(2,2-dimethylpropanoyl)-L-ornithine