Literature summary for 3.5.1.12 extracted from

So, A.K.; Kaur, J.; Kak, I.; Assi, J.; MacMillan, C.; Ralhan, R.; Walfish, P.G.
Biotinidase is a novel marker for papillary thyroid cancer aggressiveness (2012), PLoS ONE, 7, e40956.

Search for more literature for 3.5.1.12

Application

Application	Comment	Organism
diagnostics	loss of overall biotinidase expression is a marker for papillary thyroid cancer aggressiveness acting as a predictor of disease progression and prognosis	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
enzyme expression and immunohistochemic analysis in 169 different samples of thyroid cancer, overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	correlation of biotinidase expression with clinico-pathological parameters of thyroid cancer patients, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P43251	gene BTD	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thyroid cancer cell	enzyme expression analysis in 129 papillary thyroid cancers, 34 benign thyroid tissues and 43 FNA samples. The overall biotinidase expression is decreased in papillary thyroid cancers compared to benign nodules	Homo sapiens	-

General Information

General Information	Comment	Organism
malfunction	loss of overall biotinidase expression is associated with poor disease free survival in case of thyroid cancer, effect of subcellular compartmentalization of nuclear and cytoplasmic biotinidase on patient survival, correlation of biotinidase expression with clinico-pathological parameters of thyroid cancer patients, overview	Homo sapiens

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Release 2023.1 (January 2023)