Application | Comment | Organism |
---|---|---|
medicine | plasma biotinidase activity assay for diagnosis and screen newborn infants for biotinidase deficiency, treatment of inborn metabolism errors with large doses of biotin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
biotin | competitive inhibition at acidic pH, no inhibition at ph 7.4 with p-(N-biotinylamino)benzoic acid as substrate | Enterococcus faecalis | |
biotin | competitive inhibition at acidic pH, no inhibition at ph 7.4 with p-(N-biotinylamino)benzoic acid as substrate | Homo sapiens | |
biotin | competitive inhibition at acidic pH, no inhibition at ph 7.4 with p-(N-biotinylamino)benzoic acid as substrate | Sus scrofa | |
CuCl2 | - |
Homo sapiens | |
CuCl2 | - |
Rattus rattus | |
guanidine hydrochloride | 0.5 M | Homo sapiens | |
Urea | 0.5 M | Homo sapiens | |
ZnCl2 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
epsilon-N-biotinyl-L-lysine | human serum | Homo sapiens | |
0.0065 | - |
epsilon-N-biotinyl-L-lysine | human plasma | Homo sapiens | |
0.0077 | - |
epsilon-N-biotinyl-L-lysine | pH 5.5 | Homo sapiens | |
0.0078 | - |
epsilon-N-biotinyl-L-lysine | pH 7 | Homo sapiens | |
0.008 | - |
epsilon-N-biotinyl-L-lysine | serum | Sus scrofa | |
0.01 | - |
epsilon-N-biotinyl-L-lysine | porcine liver | Sus scrofa | |
0.016 | - |
epsilon-N-biotinyl-L-lysine | kidney | Sus scrofa | |
0.0306 | - |
p-(N-biotinylamino)benzoic acid | pH 5.5, D-biotin as inhibitor | Homo sapiens | |
0.0319 | - |
p-(N-biotinylamino)benzoic acid | pH 5.5 | Homo sapiens | |
0.0333 | - |
p-(N-biotinylamino)benzoic acid | pH 7 | Homo sapiens | |
0.0341 | - |
p-(N-biotinylamino)benzoic acid | pH 7, D-biocytin as inhibitor | Homo sapiens | |
0.0685 | - |
N-DL-desthiobiotinyl-p-aminobenzoic acid | pH 7 | Homo sapiens | |
0.0714 | - |
N-DL-desthiobiotinyl-p-aminobenzoic acid | pH 5.5 | Homo sapiens | |
0.0905 | - |
m-(N-biotinylamino)benzoic acid | pH 5.5 | Homo sapiens | |
0.1002 | - |
m-(N-biotinylamino)benzoic acid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus rattus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
- |
Sus scrofa |
68000 | - |
gel filtration, SDS-PAGE, sedimentation analysis | Homo sapiens |
76000 | - |
- |
Homo sapiens |
76000 | - |
gel filtration, SDS-PAGE | Sus scrofa |
80000 | - |
SDS-PAGE | Homo sapiens |
110000 | - |
gel filtration | Homo sapiens |
115000 | - |
- |
Homo sapiens |
115000 | - |
gel filtration | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
biotin amide + H2O | Homo sapiens | - |
? | - |
? | |
biotin amide + H2O | Sus scrofa | - |
? | - |
? | |
biotin amide + H2O | Enterococcus faecalis | - |
? | - |
? | |
biotin amide + H2O | Rattus rattus | - |
? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | Homo sapiens | - |
? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | Sus scrofa | - |
? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | Enterococcus faecalis | - |
? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | Rattus rattus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecalis | - |
- |
- |
Homo sapiens | - |
human | - |
Rattus rattus | - |
rat | - |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Enterococcus faecalis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | serum, plasma, leukocytes | Homo sapiens | - |
blood | serum, plasma, leukocytes | Sus scrofa | - |
blood | serum, plasma, leukocytes | Rattus rattus | - |
liver | - |
Homo sapiens | - |
liver | - |
Sus scrofa | - |
liver | - |
Rattus rattus | - |
small intestine | - |
Homo sapiens | - |
small intestine | - |
Rattus rattus | - |
stomach | - |
Rattus rattus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biotin amide + H2O | - |
Homo sapiens | ? | - |
? | |
biotin amide + H2O | - |
Sus scrofa | ? | - |
? | |
biotin amide + H2O | - |
Enterococcus faecalis | ? | - |
? | |
biotin amide + H2O | - |
Rattus rattus | ? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Homo sapiens | biotin + L-lysine | - |
ir | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Sus scrofa | biotin + L-lysine | - |
ir | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Enterococcus faecalis | biotin + L-lysine | - |
ir | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Rattus rattus | biotin + L-lysine | - |
ir | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Homo sapiens | ? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Sus scrofa | ? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Enterococcus faecalis | ? | - |
? | |
epsilon-N-biotinyl-L-lysine + H2O | - |
Rattus rattus | ? | - |
? | |
N-(+)biotinyl-4-aminobenzoic acid + H2O | - |
Homo sapiens | 4-aminobenzoic acid + biotin | - |
? | |
N-biotinyl-3-aminobenzoic acid + H2O | - |
Homo sapiens | biotin + 3-aminobenzoic acid | - |
? | |
N-biotinyl-3-aminobenzoic acid + H2O | - |
Sus scrofa | biotin + 3-aminobenzoic acid | - |
? | |
N-DL-dethiobiotinyl-p-aminobenzoic acid + H2O | - |
Homo sapiens | dethiobiotin + 4-aminobenzoic acid | - |
? | |
p-(N-biotinylamino)benzoic acid + H2O | - |
Homo sapiens | biotin + p-aminobenzoic acid | - |
ir | |
p-(N-biotinylamino)benzoic acid + H2O | - |
Sus scrofa | biotin + p-aminobenzoic acid | - |
ir | |
p-(N-biotinylamino)benzoic acid + H2O | - |
Enterococcus faecalis | biotin + p-aminobenzoic acid | - |
ir | |
p-(N-biotinylamino)benzoic acid + H2O | - |
Rattus rattus | biotin + p-aminobenzoic acid | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 68000, SDS-PAGE | Homo sapiens |
monomer | 1 * 68000, SDS-PAGE | Sus scrofa |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | 70 | - |
Sus scrofa |
60 | 70 | - |
Rattus rattus |
60 | 70 | 15 min 60°C 60% activity lost, 70°C activity completely lost | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | 6 | with natural substrate biocytin | Homo sapiens |
6 | 7.5 | with synthetic substrates | Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5 | 7 | - |
Homo sapiens |