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Literature summary for 3.5.1.12 extracted from

  • Knappe, J.; Bruemer, W.; Biederbick, K.
    Reinigung und Eigenschaften der Biotinidase aus Schweinenieren und Lactobacillus casei (1963), Biochem. Z., 338, 599-613.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
biotin competitive inhibition at acidic pH, no inhibition at ph 7.4 with p-(N-biotinylamino)benzoic acid as substrate Enterococcus faecalis
biotin competitive inhibition at acidic pH, no inhibition at ph 7.4 with p-(N-biotinylamino)benzoic acid as substrate Homo sapiens
biotin competitive inhibition at acidic pH, no inhibition at ph 7.4 with p-(N-biotinylamino)benzoic acid as substrate Lacticaseibacillus casei
biotin competitive inhibition at acidic pH, no inhibition at ph 7.4 with p-(N-biotinylamino)benzoic acid as substrate Sus scrofa
diisopropylfluorophosphate
-
Lacticaseibacillus casei
diisopropylfluorophosphate
-
Rattus rattus
diisopropylfluorophosphate
-
Sus scrofa
iodoacetamide
-
Homo sapiens
iodoacetamide
-
Sus scrofa
p-hydroxymercuribenzoate
-
Homo sapiens
p-hydroxymercuribenzoate
-
Rattus rattus
p-hydroxymercuribenzoate
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0042
-
p-(N-biotinylamino)benzoic acid
-
Sus scrofa
0.016
-
epsilon-N-biotinyl-L-lysine
-
Sus scrofa
0.02
-
p-(N-biotinylamino)benzoic acid
-
Lacticaseibacillus casei
0.85
-
N-(1'-N-methoxycarbonyl-biotinyl)p-aminobenzoic acid
-
Sus scrofa
5
-
1'-N-methoxycarbonyl-biocytin
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biotin amide + H2O Homo sapiens
-
?
-
?
biotin amide + H2O Sus scrofa
-
?
-
?
biotin amide + H2O Enterococcus faecalis
-
?
-
?
biotin amide + H2O Lacticaseibacillus casei
-
?
-
?
biotin amide + H2O Rattus rattus
-
?
-
?
epsilon-N-biotinyl-L-lysine + H2O Homo sapiens
-
?
-
?
epsilon-N-biotinyl-L-lysine + H2O Sus scrofa
-
?
-
?
epsilon-N-biotinyl-L-lysine + H2O Enterococcus faecalis
-
?
-
?
epsilon-N-biotinyl-L-lysine + H2O Lacticaseibacillus casei
-
?
-
?
epsilon-N-biotinyl-L-lysine + H2O Rattus rattus
-
?
-
?

Organic Solvent Stability

Organic Solvent Comment Organism
urea 50% activity in 3 M solution Lacticaseibacillus casei

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-
Homo sapiens
-
human
-
Lacticaseibacillus casei
-
-
-
no activity in Achromobacter sp.
-
-
-
no activity in Lactobacillus arabinosus
-
-
-
Rattus rattus
-
rat
-
Sus scrofa
-
pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa
-
Lacticaseibacillus casei

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-
heart
-
Rattus rattus
-
kidney
-
Homo sapiens
-
kidney
-
Sus scrofa
-
kidney
-
Rattus rattus
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
liver
-
Rattus rattus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2 0.3
-
Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, mercaptoethanol, a few months without loss of activity Sus scrofa
-20°C, phosphate buffer pH 7.5, a few months Lacticaseibacillus casei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1'-N-methoxycarbonyl-biocytin + H2O
-
Sus scrofa 1-N-methoxycarbonyl-biotin + L-lysine
-
?
2-(N-biotinyl)-amino-5-nitro-benzoic acid + H2O
-
Sus scrofa biotin + 2-amino-5-nitrobenzoic acid
-
?
2-(N-biotinyl)-amino-5-nitro-benzoic acid + H2O
-
Lacticaseibacillus casei biotin + 2-amino-5-nitrobenzoic acid
-
?
3-(N-biotinyl)-amino-6-nitrobenzoic acid + H2O
-
Sus scrofa biotin + 3-amino-6-nitrobenzoic acid
-
?
3-(N-biotinyl)-amino-6-nitrobenzoic acid + H2O
-
Lacticaseibacillus casei biotin + 3-amino-6-nitrobenzoic acid
-
?
biotin amide + H2O
-
Homo sapiens ?
-
?
biotin amide + H2O
-
Sus scrofa ?
-
?
biotin amide + H2O
-
Enterococcus faecalis ?
-
?
biotin amide + H2O
-
Lacticaseibacillus casei ?
-
?
biotin amide + H2O
-
Rattus rattus ?
-
?
biotin methyl ester + H2O
-
Sus scrofa ?
-
?
biotin methyl ester + H2O
-
Enterococcus faecalis ?
-
?
biotin methyl ester + H2O
-
Lacticaseibacillus casei ?
-
?
biotinyl-L-aspartate + H2O
-
Sus scrofa biotin + L-aspartate
-
?
biotinyl-L-aspartate + H2O
-
Enterococcus faecalis biotin + L-aspartate
-
?
biotinyl-L-aspartate + H2O
-
Lacticaseibacillus casei biotin + L-aspartate
-
?
epsilon-N-biotinyl-L-lysine + H2O
-
Homo sapiens biotin + L-lysine
-
ir
epsilon-N-biotinyl-L-lysine + H2O
-
Sus scrofa biotin + L-lysine
-
ir
epsilon-N-biotinyl-L-lysine + H2O
-
Enterococcus faecalis biotin + L-lysine
-
ir
epsilon-N-biotinyl-L-lysine + H2O
-
Lacticaseibacillus casei biotin + L-lysine
-
ir
epsilon-N-biotinyl-L-lysine + H2O
-
Rattus rattus biotin + L-lysine
-
ir
epsilon-N-biotinyl-L-lysine + H2O
-
Homo sapiens ?
-
?
epsilon-N-biotinyl-L-lysine + H2O
-
Sus scrofa ?
-
?
epsilon-N-biotinyl-L-lysine + H2O
-
Enterococcus faecalis ?
-
?
epsilon-N-biotinyl-L-lysine + H2O
-
Lacticaseibacillus casei ?
-
?
epsilon-N-biotinyl-L-lysine + H2O
-
Rattus rattus ?
-
?
N-(1'-N-methoxycarbonyl-biotinyl)p-aminobenzoic acid + H2O
-
Sus scrofa 1-N-methoxycarbonyl-biotin + 4-aminobenzoic acid
-
?
N-biotinyl-beta-alanine + H2O
-
Sus scrofa biotin + beta-alanine
-
?
N-biotinyl-beta-alanine + H2O
-
Enterococcus faecalis biotin + beta-alanine
-
?
N-biotinyl-beta-alanine + H2O
-
Lacticaseibacillus casei biotin + beta-alanine
-
?
p-(N-biotinylamino)benzoic acid + H2O
-
Homo sapiens biotin + p-aminobenzoic acid
-
ir
p-(N-biotinylamino)benzoic acid + H2O
-
Sus scrofa biotin + p-aminobenzoic acid
-
ir
p-(N-biotinylamino)benzoic acid + H2O
-
Enterococcus faecalis biotin + p-aminobenzoic acid
-
ir
p-(N-biotinylamino)benzoic acid + H2O
-
Lacticaseibacillus casei biotin + p-aminobenzoic acid
-
ir
p-(N-biotinylamino)benzoic acid + H2O
-
Rattus rattus biotin + p-aminobenzoic acid
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Sus scrofa
6
-
-
Rattus rattus
7
-
-
Lacticaseibacillus casei

pH Range

pH Minimum pH Maximum Comment Organism
4.5 7.5
-
Sus scrofa
5.3 9.5
-
Lacticaseibacillus casei