Application | Comment | Organism |
---|---|---|
synthesis | PVA is a pharmaceutically important enzyme to produce 6-aminopenicillanic acid | Buckleyzyma aurantiaca |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-bromosuccinimide | - |
Buckleyzyma aurantiaca | |
Phenylmethylsulfonylfluoride | - |
Buckleyzyma aurantiaca |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
penicillin V + H2O | Buckleyzyma aurantiaca | - |
phenoxyacetate + 6-aminopenicillinate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Buckleyzyma aurantiaca | - |
NCIM 3425 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
penicillin V + H2O | - |
Buckleyzyma aurantiaca | phenoxyacetate + 6-aminopenicillinate | - |
? | |
penicillin V + H2O | involvement of serine and tryptophan in the enzyme activity | Buckleyzyma aurantiaca | phenoxyacetate + 6-aminopenicillinate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | penicillin acylases share a common structural fold and possess a catalytic serine or cysteine or threonine residue at the N-terminal end | Buckleyzyma aurantiaca |
Synonyms | Comment | Organism |
---|---|---|
More | PVA is a member of the N-terminal nucleophile, Ntn, hydrolase superfamily | Buckleyzyma aurantiaca |
penicillin V acylase | - |
Buckleyzyma aurantiaca |
PVA | - |
Buckleyzyma aurantiaca |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, effects of tryptophan and serine modifications by phenylmethylsulfonylfluoride and N-bromosuccinimide, fluorometric studies, overview | Buckleyzyma aurantiaca |