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Literature summary for 3.5.1.11 extracted from

  • Ribeiro, M.P.; Ferreira, A.L.; Giordano, R.L.; Giordano, R.C.
    Selectivity of the enzymatic synthesis of ampicillin by E. coli PGA in the presence of high concentrations of substrates (2005), J. Mol. Catal. B, 33, 81-86.
No PubMed abstract available

Application

Application Comment Organism
synthesis synthesis of ampicillin. High ratio of synthesis to hydrolysis at up to 200 mM 6-aminopenicillic acid and 500 mM D-phenylglycine methyl ester at 25°C and pH 6.5. When concentration of 6-aminopenicillic acid reaches saturation, rate of hydrolysis tends toward zero Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-phenylglycine methyl ester + 6-aminopenicillic acid high ratio of synthesis to hydrolysis at up to 200 mM 6-aminopenicillic acid and 500 mM D-phenylglycine methyl ester at 25°C and pH 6.5. When concentration of 6-aminopenicillic acid reaches saturation, rate of hydrolysis tends toward zero Escherichia coli ampicillin + methanol
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r