Application | Comment | Organism |
---|---|---|
synthesis | enzyme-catalyzed synthesis of beta-lactam antibiotics in supersaturated solutions of substrates. Due to nucleophile supersaturation, ratio of synthesis/hydrolysis be be increased up to threefold | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amoxicillin + H2O | - |
Escherichia coli | D-4-hydroxyphenylglycine amide + 6-aminopenicillanic acid | - |
r | |
ampicillin + H2O | - |
Escherichia coli | (R)-2-phenylglycine + 6-aminopenicillanic acid | - |
r | |
cephalexin + H2O | - |
Escherichia coli | D-phenylglycine + 7-aminodesacetoxycephalosporanic acid | - |
r | |
D-4-hydroxyphenylglycine amide + 6-aminopenicillanic acid | - |
Escherichia coli | amoxicillin + NH3 | - |
r | |
D-phenylglycine amide + 6-aminopenicillanic acid | - |
Escherichia coli | ampicillin + NH3 | - |
r | |
D-phenylglycine amide + 7-aminodesacetoxycephalosporanic acid | - |
Escherichia coli | cephalexin + NH3 | - |
r |