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Literature summary for 3.5.1.11 extracted from

  • Youshko, M.I.; Moody, H.M.; Bukhanov, A.L.; Boosten, W.H.; Svedas, V.K.
    Penicillin acylase-catalyzed synthesis of beta-lactam antibiotics in highly condensed aqueous systems: beneficial impact of kinetic substrate supersaturation (2004), Biotechnol. Bioeng., 85, 323-329.
    View publication on PubMed

Application

Application Comment Organism
synthesis enzyme-catalyzed synthesis of beta-lactam antibiotics in supersaturated solutions of substrates. Due to nucleophile supersaturation, ratio of synthesis/hydrolysis be be increased up to threefold Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amoxicillin + H2O
-
Escherichia coli D-4-hydroxyphenylglycine amide + 6-aminopenicillanic acid
-
r
ampicillin + H2O
-
Escherichia coli (R)-2-phenylglycine + 6-aminopenicillanic acid
-
r
cephalexin + H2O
-
Escherichia coli D-phenylglycine + 7-aminodesacetoxycephalosporanic acid
-
r
D-4-hydroxyphenylglycine amide + 6-aminopenicillanic acid
-
Escherichia coli amoxicillin + NH3
-
r
D-phenylglycine amide + 6-aminopenicillanic acid
-
Escherichia coli ampicillin + NH3
-
r
D-phenylglycine amide + 7-aminodesacetoxycephalosporanic acid
-
Escherichia coli cephalexin + NH3
-
r