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Literature summary for 3.5.1.108 extracted from

  • Mansoor, U.F.; Vitharana, D.; Reddy, P.A.; Daubaras, D.L.; McNicholas, P.; Orth, P.; Black, T.; Siddiqui, M.A.
    Design and synthesis of potent Gram-negative specific LpxC inhibitors (2011), Bioorg. Med. Chem. Lett., 21, 1155-1161.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-[[4-(diethylamino)-2-hydroxyphenyl]carbonyl]benzoic acid compound shows good activity against Escherichia coli and Pseudomonas aeruginosa Escherichia coli
N-[3-amino-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide compound shows good activity against Escherichia coli and Pseudomonas aeruginosa Escherichia coli
N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide compound shows good activity against Escherichia coli and Pseudomonas aeruginosa Escherichia coli
N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide compound shows good activity against Escherichia coli and Pseudomonas aeruginosa Escherichia coli
N-[3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide compound shows good activity against Escherichia coli and Pseudomonas aeruginosa Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000003
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli N-[3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
0.0000006
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli N-[3-amino-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
0.000002
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 2-[[4-(diethylamino)-2-hydroxyphenyl]carbonyl]benzoic acid
0.0000024
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
0.0000138
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide