Cloned (Comment) | Organism |
---|---|
the paLpxC (residues 1-299, C40S) is cloned from genomic DNA by polymerase chain reaction and inserted into pPW4 expression vectors. The recombinant paLpxC is overexpressed | Pseudomonas aeruginosa |
Crystallization (Comment) | Organism |
---|---|
1.9 A resolution crystal structure of LpxC complexed with (2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide | potent inhibitor, shows antibacterial activity against a wide range of Gram-negative pathogens, binding mode | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | P47205 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Pseudomonas aeruginosa |
Synonyms | Comment | Organism |
---|---|---|
LpxC | - |
Pseudomonas aeruginosa |
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase | - |
Pseudomonas aeruginosa |