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Literature summary for 3.5.1.108 extracted from

  • Mochalkin, I.; Knafels, J.D.; Lightle, S.
    Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor. (2008), Protein Sci., 17, 450-457.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
the paLpxC (residues 1-299, C40S) is cloned from genomic DNA by polymerase chain reaction and inserted into pPW4 expression vectors. The recombinant paLpxC is overexpressed Pseudomonas aeruginosa

Crystallization (Commentary)

Crystallization (Comment) Organism
1.9 A resolution crystal structure of LpxC complexed with (2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide potent inhibitor, shows antibacterial activity against a wide range of Gram-negative pathogens, binding mode Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa P47205
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
LpxC
-
 Pseudomonas aeruginosa
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
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 Pseudomonas aeruginosa