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Literature summary for 3.5.1.108 extracted from

  • Langsdorf, E.F.; Malikzay, A.; Lamarr, W.A.; Daubaras, D.; Kravec, C.; Zhang, R.; Hart, R.; Monsma, F.; Black, T.; Ozbal, C.C.; Miesel, L.; Lunn, C.A.
    Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay (2009), J. Biomol. Screen., 15, 52-61.
    View publication on PubMed
Search for more literature for 3.5.1.108

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information mass spectrometry-based screening is a valuable high-throughput screening tool for detecting inhibitors of enzymatic targets involving difficult to detect reactions Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O Escherichia coli this reaction is essential in the biosynthesis of lipopolysaccharide (LPS) of Gram-negative bacteria and is an attractive target for the development of new antibacterial agents UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
-
 Escherichia coli UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O this reaction is essential in the biosynthesis of lipopolysaccharide (LPS) of Gram-negative bacteria and is an attractive target for the development of new antibacterial agents Escherichia coli UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
UDP-3-O-(R-3-hydroxymyristoyl)-Nacetylglucosamine deacetylase
-
 Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.283
-
 UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine pH 7.3 Escherichia coli