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Literature summary for 3.5.1.108 extracted from

  • Kadam, R.U.; Garg, D.; Roy, N.
    Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential (2008), Chem. Biol. Drug Des., 71, 45-56.
    View publication on PubMed

Application

Application Comment Organism
drug development target for development of anti-infective drugs against gram-negative bacteria Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
(R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol
-
Pseudomonas aeruginosa
(R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
-
Pseudomonas aeruginosa
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
-
Pseudomonas aeruginosa
(R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
Pseudomonas aeruginosa
(R)-N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
-
Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
-
Pseudomonas aeruginosa UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
?

Synonyms

Synonyms Comment Organism
deacetylase LpxC
-
Pseudomonas aeruginosa
LpxC
-
Pseudomonas aeruginosa
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase
-
Pseudomonas aeruginosa
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase enzyme
-
Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
above 30 microM Pseudomonas aeruginosa (R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
additional information
-
above 50 microM Pseudomonas aeruginosa (R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
0.00016
-
-
Pseudomonas aeruginosa (R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.00025
-
-
Pseudomonas aeruginosa (R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0005
-
-
Pseudomonas aeruginosa (R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.00056
-
-
Pseudomonas aeruginosa (R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.001
-
-
Pseudomonas aeruginosa (R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.001
-
-
Pseudomonas aeruginosa (R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.0012
-
-
Pseudomonas aeruginosa (R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0022
-
-
Pseudomonas aeruginosa (R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0049
-
-
Pseudomonas aeruginosa (R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0055
-
-
Pseudomonas aeruginosa (R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
0.01
-
-
Pseudomonas aeruginosa (R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.012
-
-
Pseudomonas aeruginosa (R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.013
-
-
Pseudomonas aeruginosa (R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
0.0178
-
-
Pseudomonas aeruginosa (R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol
0.025
-
-
Pseudomonas aeruginosa (R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0385
-
-
Pseudomonas aeruginosa (R)-N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide