Application | Comment | Organism |
---|---|---|
drug development | target for development of anti-infective drugs against gram-negative bacteria | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol | - |
Pseudomonas aeruginosa | |
(R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide | - |
Pseudomonas aeruginosa | |
(R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
(R)-N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide | - |
Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O | - |
Pseudomonas aeruginosa | UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deacetylase LpxC | - |
Pseudomonas aeruginosa |
LpxC | - |
Pseudomonas aeruginosa |
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase | - |
Pseudomonas aeruginosa |
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase enzyme | - |
Pseudomonas aeruginosa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
above 30 microM | Pseudomonas aeruginosa | (R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide | |
additional information | - |
above 50 microM | Pseudomonas aeruginosa | (R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide | |
0.00016 | - |
- |
Pseudomonas aeruginosa | (R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
0.00025 | - |
- |
Pseudomonas aeruginosa | (R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.0005 | - |
- |
Pseudomonas aeruginosa | (R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
0.00056 | - |
- |
Pseudomonas aeruginosa | (R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
0.001 | - |
- |
Pseudomonas aeruginosa | (R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.001 | - |
- |
Pseudomonas aeruginosa | (R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
0.0012 | - |
- |
Pseudomonas aeruginosa | (R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.0022 | - |
- |
Pseudomonas aeruginosa | (R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.0049 | - |
- |
Pseudomonas aeruginosa | (R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.0055 | - |
- |
Pseudomonas aeruginosa | (R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide | |
0.01 | - |
- |
Pseudomonas aeruginosa | (R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.012 | - |
- |
Pseudomonas aeruginosa | (R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.013 | - |
- |
Pseudomonas aeruginosa | (R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide | |
0.0178 | - |
- |
Pseudomonas aeruginosa | (R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol | |
0.025 | - |
- |
Pseudomonas aeruginosa | (R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.0385 | - |
- |
Pseudomonas aeruginosa | (R)-N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide |