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Literature summary for 3.5.1.108 extracted from

  • Kadam, R.U.; Roy, N.
    Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors (2006), Bioorg. Med. Chem. Lett., 16, 5136-5143.
    View publication on PubMed
Search for more literature for 3.5.1.108

Application

Application Comment Organism
drug development enzyme is an attractive target against Pseudomonas infection Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-fluoro-4-(3-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-(heptyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-acetamidophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
3-ethoxy-4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
 Pseudomonas aeruginosa
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
-
 Pseudomonas aeruginosa
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
 Pseudomonas aeruginosa
4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
 Pseudomonas aeruginosa
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
-
 Pseudomonas aeruginosa
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-(trifluoromethoxy)benzamide
-
 Pseudomonas aeruginosa
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
-
 Pseudomonas aeruginosa
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methylbenzamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(2-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide
-
 Pseudomonas aeruginosa
N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
-
 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Synonyms

Synonyms Comment Organism
deacetylase LpxC
-
 Pseudomonas aeruginosa
LpxC
-
 Pseudomonas aeruginosa
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase
-
 Pseudomonas aeruginosa