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Literature summary for 3.4.25.2 extracted from

  • Rashid, Y.; Kamran Azim, M.; Saify, Z.S.; Khan, K.M.; Khan, R.
    Small molecule activators of proteasome-related HslV peptidase (2012), Bioorg. Med. Chem. Lett., 22, 6089-6094.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1-(3,4-dihydroxyphenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
Escherichia coli
1-(3,4-dihydroxyphenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
Haemophilus influenzae
1-(4-nitrophenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
Escherichia coli
1-(4-nitrophenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
Haemophilus influenzae
3-{(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-2-(4-nitrophenyl)quinazolin-4(3H)-one
-
Escherichia coli
3-{(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-2-(4-nitrophenyl)quinazolin-4(3H)-one
-
Haemophilus influenzae
HslU ATPase natural activator Escherichia coli
HslU ATPase natural activator Haemophilus influenzae
N'-[(E)-(4-oxo-4H-chromen-2-yl)methylidene]benzohydrazide
-
Escherichia coli
N'-[(E)-(4-oxo-4H-chromen-2-yl)methylidene]benzohydrazide
-
Haemophilus influenzae

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Haemophilus influenzae P43772
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbobenzoxy-Gly-Gly-Leu-7-amido-4-methyl coumarin + H2O the HslV peptidase alone shows a very weak peptidase activity towards carbobenzoxy-Gly-Gly-Leu-7-amido-4-methyl coumarin, but its activity increases 1-2 orders of magnitude when it binds to HslU in the presence of ATP Escherichia coli carbobenzoxy-Gly-Gly-Leu + 7-amino-4-methyl coumarin
-
?
carbobenzoxy-Gly-Gly-Leu-7-amido-4-methylcoumarin + H2O The HslV peptidase alone shows a very weak peptidase activity towards carbobenzoxy-Gly-Gly-Leu-7-amido-4-methyl coumarin, but its activity increases 1-2 orders of magnitude when it binds to HslU in the presence of ATP Haemophilus influenzae carbobenzoxy-Gly-Gly-Leu + 7-amino-4-methylcoumarin
-
?

Subunits

Subunits Comment Organism
dodecamer
-
Escherichia coli
dodecamer
-
Haemophilus influenzae

Synonyms

Synonyms Comment Organism
HslV peptidase
-
Escherichia coli
HslV peptidase
-
Haemophilus influenzae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Escherichia coli
ATP
-
Haemophilus influenzae