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Literature summary for 3.4.24.B7 extracted from
- Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro (2011), Exp. Mol. Pathol., 92, 59-63.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | slight, but significant, downregulation of MMP-26 in more degenerated intervertebral discs (Thompson grades III, IV and V) compared to healthier discs, while both TGF-beta and latent transforming growth factor-beta binding protein 2 are significantly and strongly upregulated | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| activated pro-MMP-9 + H2O | Homo sapiens | - |
? | - |
? |  |
| denatured collagen type I + H2O | Homo sapiens | - |
? | - |
? | |
| denatured collagen type II + H2O | Homo sapiens | - |
? | - |
? | |
| denatured collagen type III + H2O | Homo sapiens | - |
? | - |
? | |
| denatured collagen type IV + H2O | Homo sapiens | - |
? | - |
? | |
| Fibrinogen + H2O | Homo sapiens | - |
? | - |
? | |
| Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
| insulin-like growth factor binding protein 1 + H2O | Homo sapiens | - |
? | - |
? | |
| Type IV collagen + H2O | Homo sapiens | - |
? | - |
? | |
| Vitronectin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | Q9NRE1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| annulus fibrosus disci intervertebralis | - |
Homo sapiens | - |
| intervertebral disc | in the outer and inner annulus and in the nucleus pulposus | Homo sapiens | - |
| intervertebral disc | constitutive expression. Protein is found in both disc cells and in the disc extracellular matrix. MMP-26 is identified in the outer and inner annulus and in the nucleus pulposus. Fewer cells show localization in the inner vs. outer annulus, and localization is sparse in the nucleus | Homo sapiens | - |
| nucleus pulposus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| activated pro-MMP-9 + H2O | - |
Homo sapiens | ? | - |
? | |
| denatured collagen type I + H2O | - |
Homo sapiens | ? | - |
? | |
| denatured collagen type II + H2O | - |
Homo sapiens | ? | - |
? | |
| denatured collagen type III + H2O | - |
Homo sapiens | ? | - |
? | |
| denatured collagen type IV + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| insulin-like growth factor binding protein 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| Type IV collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| endometase | - |
Homo sapiens |
| matrilysin-2 | - |
Homo sapiens |
| MMP-26 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | there is significant downregulation of expression of MMP-26 in more degenerated discs vs. healthier discs | down |
| Homo sapiens | significant downregulation of expression of MMP-26, and significant 9.8fold upregulation of TGF-beta in more degenerated discs versus healthier discs | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | MMP-26 plays an important role of in matrix modulation during disc health and degeneration | Homo sapiens |
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