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Literature summary for 3.4.24.80 extracted from

  • Nisato, R.E.; Hosseini, G.; Sirrenberg, C.; Butler, G.S.; Crabbe, T.; Docherty, A.J.; Wiesner, M.; Murphy, G.; Overall, C.M.; Goodman, S.L.; Pepper, M.S.
    Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical (2005), Cancer Res., 65, 9377-9387.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cytokine protein levels of the enzyme significantly increase by FGF-2 plus VEGF-A, only slightly by FGF-1, and not at all by VEGF-A Bos taurus

Application

Application Comment Organism
medicine endothelial cell invasion of collagen I gels is MT1-MMP dependent Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
anti-membrane-type 1-MMP antibody antibodies LEM-1 and LEM-2 inhibit endothelial cell invasion in a dose dependent manner Bos taurus
BB94 inhibits endothelial cell invasion Bos taurus
CT1399 inhibits endothelial cell invasion Bos taurus
CT1847 inhibits endothelial cell invasion Bos taurus
additional information TIMP-1 does not inhibit endothelial cell invasion Bos taurus
TIMP-2 inhibits endothelial cell invasion Bos taurus
TIMP-3 inhibits endothelial cell invasion Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta endothelium
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Bos taurus
-

Synonyms

Synonyms Comment Organism
membrane type 1 MMP
-
Bos taurus
MT1-MMP
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Bos taurus