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Literature summary for 3.4.24.75 extracted from

  • Kokai-Kun, J.F.; Chanturiya, T.; Mond, J.J.
    Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model (2007), J. Antimicrob. Chemother., 60, 1051-1059.
    View publication on PubMed
Search for more literature for 3.4.24.75

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme acts synergistically with oxacillin and with vancomycin in lysis of the cell wall of pathogenic Staphylococcus aureus Staphylococcus simulans

Application

Application Comment Organism
pharmacology lysostaphin is useful for treatment for systemic Staphylococcus aureus infection in a mouse model Staphylococcus simulans

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Staphylococcus simulans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics of lysostaphin clearance of Staphylococcus aureus infection, overview Staphylococcus simulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Staphylococcus simulans the endopeptidase rapidly lyses Staphylococcus aureus through proteolysis of the staphylococcal cell wall which allows its use as a therapeutic agent, the enzyme acts synergistically with oxacillin and with vancomycin, in vivo antimicrobial activity in different mouse tissues, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus simulans
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-
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Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from Escherichia coli Staphylococcus simulans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the endopeptidase rapidly lyses Staphylococcus aureus through proteolysis of the staphylococcal cell wall which allows its use as a therapeutic agent, the enzyme acts synergistically with oxacillin and with vancomycin, in vivo antimicrobial activity in different mouse tissues, overview Staphylococcus simulans ?
-
 ?