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Literature summary for 3.4.24.56 extracted from

  • Cordes, C.; Bennett, R.; Siford, G.; Hamel, F.
    Redox regulation of insulin degradation by insulin-degrading enzyme (2011), PLoS ONE, 6, e18138.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.56

Inhibitors

Inhibitors Comment Organism Structure
glutathione oxidized glutathione inhibits IDE through glutathionylation, which is reversible by dithiothreitol but not by ascorbic acid Rattus norvegicus
S-nitrosoglutathione inhibits IDE-mediated degradation of two IDE substrates, insulin and amyloid beta Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta peptide + H2O
-
 Rattus norvegicus ?
-
 ?
insulin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
IDE
-
 Rattus norvegicus
Insulysin
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus