Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein ANP | - |
Homo sapiens | |
protein BNP | - |
Homo sapiens | |
protein CNP | - |
Homo sapiens | |
protein DNP | - |
Homo sapiens | |
urodilatin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)acetyl-RPPGFSAFK-2,4-dinitrophenyl + H2O | - |
Homo sapiens | ? | - |
? | |
protein ANP + H2O | - |
Homo sapiens | ? | - |
? | |
protein BNP + H2O | - |
Homo sapiens | ? | - |
? | |
protein CNP + H2O | - |
Homo sapiens | ? | - |
? | |
protein DNP + H2O | - |
Homo sapiens | ? | - |
? | |
urodilatin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Homo sapiens |
Insulin-degrading enzyme | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
protein DNP | pH not specified in the publication, 37°C | Homo sapiens | |
0.2 | - |
protein BNP | pH not specified in the publication, 37°C | Homo sapiens | |
2 | - |
urodilatin | pH not specified in the publication, 37°C | Homo sapiens | |
10 | - |
protein ANP | pH not specified in the publication, 37°C | Homo sapiens | |
20 | - |
protein CNP | pH not specified in the publication, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.04 | - |
pH not specified in the publication, 37°C | Homo sapiens | protein ANP | |
0.07 | - |
pH not specified in the publication, 37°C | Homo sapiens | protein CNP | |
0.12 | - |
pH not specified in the publication, 37°C | Homo sapiens | protein BNP | |
0.8 | - |
pH not specified in the publication, 37°C | Homo sapiens | urodilatin | |
1.3 | - |
pH not specified in the publication, 37°C | Homo sapiens | protein DNP |
General Information | Comment | Organism |
---|---|---|
malfunction | reduction of IDE expression diminishes the ability of natriuretic peptides ANP and BNP to stimulate natriuretic peptide receptor NPR-B | Homo sapiens |
physiological function | reducing expression levels of IDE profoundly alters the response of natriuretic peptide receptors (NPR-A and NPR-B) to the stimulation of ANP, BNP, and CNP in cultured cells. IDE rapidly cleaves ANP and CNP, thus inactivating their ability to raise intracellular cGMP. Reduced IDE expression enhances the stimulation of NPR-A and NPR-B by ANP and CNP, respectively. IDE cleavage can lead to hyperactivation of BNP toward NPR-A. Conversely, decreasing IDE expression reduces BNP-mediated signaling | Homo sapiens |