Literature summary for 3.4.24.56 extracted from

Carrasquillo, M.M.; Belbin, O.; Zou, F.; Allen, M.; Ertekin-Taner, N.; Ansari, M.; Wilcox, S.L.; Kashino, M.R.; Ma, L.; Younkin, L.H.; Younkin, S.G.; Younkin, C.S.; Dincman, T.A.; Howard, M.E.; Howell, C.C.; Stanton, C.M.; Watson, C.M.; Crump, M.; Vitart, V.; Hayward, C.; Hastie, N.D.; Rudan, I.; Campbell, H.; , P.
Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimers disease (2010), PLoS ONE, 5, e8764.

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, genotyping, overview	Homo sapiens

Protein Variants	Comment	Organism
additional information	identification of a genetic variant 311 rs6583817, found in two Croatian isolated populations, unequivocally associated with increased IDE expression that is also associated with reduced plasma amyloidbeta40 and decreased late onset Alzheimer's disease susceptibility. rs6583817 increases reporter gene expression in Be(2)-C and Hep-G2 cell lines. Additional eleven IDE haplotypes, that also show significant association, overview	Homo sapiens

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid beta + H2O	Homo sapiens	-	amyloid beta peptide fragments	-	?
insulin + H2O	Homo sapiens	-	insulin peptide fragments	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid beta + H2O	-	Homo sapiens	amyloid beta peptide fragments	-	?
insulin + H2O	-	Homo sapiens	insulin peptide fragments	-	?

Synonyms	Comment	Organism
IDE	-	Homo sapiens
Insulin-degrading enzyme	-	Homo sapiens