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Literature summary for 3.4.24.56 extracted from

  • Radulescu, R.T.; Duckworth, W.C.; Levy, J.L.; Fawcett, J.
    Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: implications for cell proliferation control (2010), Biochem. Biophys. Res. Commun., 395, 196-199.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm IDE colocalizes with retinoblastoma tumor suppressor protein in cancer cells, overview. The amount of retinoblastoma tumor suppressor protein-IDE complex seems to be lower in Hep-G2 cells versus MCF-7 cells with increased nuclear localization, overview Homo sapiens 5737
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additional information interplay between retinoblastoma tumor suppressor protein and IDE within the proteasome that may have important growth-regulatory consequences Homo sapiens
-
-
nucleus IDE colocalizes with retinoblastoma tumor suppressor protein in cancer cells, overview. The amount of retinoblastoma tumor suppressor protein-IDE complex seems to be lower in Hep-G2 cells versus MCF-7 cells with increased nuclear localization, overview Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
isolation of the IDE/proteasomal complex from MCF-7 cells and HepG2 cells, IDE copurifies with the retinoblastoma tumor suppressor protein, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell hepatoma cells Homo sapiens
-
MCF-7 cell breast cancer cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
IDE
-
Homo sapiens
Insulin-degrading enzyme
-
Homo sapiens

General Information

General Information Comment Organism
additional information interplay between retinoblastoma tumor suppressor protein and IDE within the proteasome that may have important growth-regulatory consequences Homo sapiens