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Literature summary for 3.4.24.56 extracted from

  • Fawcett, J.; Permana, P.A.; Levy, J.L.; Duckworth, W.C.
    Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing (2007), Arch. Biochem. Biophys., 468, 128-133.
    View publication on PubMed
Search for more literature for 3.4.24.56

Protein Variants

Protein Variants Comment Organism
additional information siRNA-mediated gene silencing of IDE in Hep-G2 cells leading to 50% reduction of IDE mRNA and protein, short-lived protein degradation is unchanged in the cells with reduced IDE expression, while long-lived and very-long-lived protein degradation is reduced, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin + H2O Homo sapiens IDE is involved in the cellular insulin metabolism, insulin inhibits protein degradation via an interaction with IDE, regulation of protein degradation by insulin-degrading enzyme, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
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liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin + H2O
-
 Homo sapiens ?
-
 ?
insulin + H2O IDE is involved in the cellular insulin metabolism, insulin inhibits protein degradation via an interaction with IDE, regulation of protein degradation by insulin-degrading enzyme, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
IDE
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 Homo sapiens
Insulin-degrading enzyme
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens