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Literature summary for 3.4.24.56 extracted from

  • Li, Q.; Ali, M.A.; Cohen, J.I.
    Insulin degrading enzyme is a cellular receptor mediating Varicella-zoster virus infection and cell-to-cell spread (2006), Cell, 127, 305-316.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is a cellular receptor for both cell-free and cell-associated Varicella-zoster virus. Enzyme interacts with Varicella-zoster virus glycoprotein E through its extracellular domain. Downregulation of enzyme by siRNA, or blocking with antibody inhibited Varicella-zoster infection. Transfection of cell lines impaired for infection with a plasmid expressing human enzyme results in increased entry and increased infection by Varicella-zoster virus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell
-
Homo sapiens
-

Subunits

Subunits Comment Organism
More enzyme interacts with Varicella zoster virus glycoprotein E through its extracellular domain Homo sapiens