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Literature summary for 3.4.24.56 extracted from

  • Morelli, L.; Llovera, R.E.; Alonso, L.G.; Frangione, B.; de Prat-Gay, G.; Ghiso, J.; Castano, E.M.
    Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia (2005), Biochem. Biophys. Res. Commun., 332, 808-816.
    View publication on PubMed
Search for more literature for 3.4.24.56

Application

Application Comment Organism
medicine enzyme is capable of cleavage of the 34 amino acid peptides resulting from internal proteolysis of genetically defect type 2 transmembrane protein BRI2 in patients with familial British dementia or familial Danish dementia. Enzymic degradation of peptide is more efficient with monomeric peptide than with aggregated peptide. Proteolysis of monomeric soluble peptide precursors by enzyme may delay peptide ABri and ADan aggregation in vivo Rattus norvegicus
medicine in isolated brain microvessels from patients with Alzheimer’s disease with cerebral amyloid angiopathy enzyme protein level is up to 44% increased, but enzyme activity is significantly reduced Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 healthy individuals and patients with Alzheimer’s disease with cerebral amyloid angiopathy
-
Rattus norvegicus
-
 recombinant enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isolated brain microvessels, in patients with Alzheimer’s disease with cerebral amyloid angiopathy enzyme protein level is up to 44% increased, but enzyme activity is significantly reduced Homo sapiens
-
cerebral cortex isolated brain microvessels, in patients with Alzheimer’s disease with cerebral amyloid angiopathy enzyme protein level is up to 44% increased, but enzyme activity is significantly reduced Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta-protein + H2O
-
 Homo sapiens ?
-
 ?
amyloid beta-protein A21G + H2O Flemish genetic variant Homo sapiens ?
-
 ?
amyloid beta-protein E22K + H2O Italian genetic variant Homo sapiens ?
-
 ?
amyloid beta-protein E22Q + H2O Dutch genetic variant Homo sapiens ?
-
 ?
amyloid peptide + H2O 23 amino acid peptide resulting from internal proteolysis of wild-type type 2 transmembrane protein BRI2 Rattus norvegicus ?
-
 ?
amyloid peptide ABri + H2O 34 amino acid peptide resulting from internal proteolysis of genetically defect type 2 transmembrane protein BRI2 in patients with familial British dementia. Enzymic degradation of peptide is more efficient with monomeric peptide than with aggregated peptide Rattus norvegicus ?
-
 ?
amyloid peptide ADan + H2O 34 amino acid peptide resulting from internal proteolysis of genetically defect type 2 transmembrane protein BRI2 in patients with familial Danish dementia Rattus norvegicus ?
-
 ?