Any feedback?
Literature summary for 3.4.24.56 extracted from
- Insulin-degrading enzyme: embarking on amyloid destruction (2001), Trends Biochem. Sci., 26, 421-425.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | stimulation of enzyme activity can provide a useful therapeutic approach in treatment of diseases caused by amyloidosis, like Alzheimer's disease, type2 non-insulin-dependent diabetes and the spongiform encephalopathies such as Creutzfeldt-Jakob disease | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA cloned and expressed | Drosophila melanogaster |
| expressed in bacteria | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00002 | - |
Insulin | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Drosophila melanogaster | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| peroxisome | - |
Drosophila melanogaster | 5777 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | contains zinc, essential for its proteolytic activity | Homo sapiens |  |
| Zn2+ | zinc metallomeptidase | Drosophila melanogaster | |
| Zn2+ | zinc metallomeptidase | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
3 * 110000, SDS-PAGE | Homo sapiens |
| 300000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
fruit fly | - |
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amylin + H2O | - |
Homo sapiens | ? | - |
? | |
| atrial natriuretic peptide + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-amyloid protein + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-amyloid protein + H2O | - |
Rattus norvegicus | ? | - |
? | |
| beta-endorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| calcitonin + H2O | - |
Homo sapiens | ? | - |
? | |
| Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
| haemoglobin + H2O | damaged haemoglobin oxidatively degraded | Homo sapiens | ? | - |
? | |
| insulin + H2O | - |
Drosophila melanogaster | ? | - |
? | |
| insulin + H2O | - |
Homo sapiens | ? | - |
? | |
| insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Lysozyme + H2O | degradation of oxidatively damaged lysozyme | Homo sapiens | ? | - |
? | |
| additional information | does not act on glucagon-like peptide 1, nerve growth factor, somatostatin, bradykinin, vasopressin, platelet-derived growth factor, and vasoactive intestinal peptide, proinsulin, epidermal growth factor and IGF-I bind to the enzyme but are not efficiently degraded | Homo sapiens | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | 3 * 110000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADE | - |
Drosophila melanogaster |
| ADE | - |
Homo sapiens |
| ADE | - |
Rattus norvegicus |
| amyloid degrading enzyme | - |
Drosophila melanogaster |
| amyloid degrading enzyme | - |
Homo sapiens |
| amyloid degrading enzyme | - |
Rattus norvegicus |
| gamma-endorphin-generating enzyme | - |
Homo sapiens |
| IDE | - |
Drosophila melanogaster |
| IDE | - |
Homo sapiens |
| IDE | - |
Rattus norvegicus |
| insulin degrading enzyme | - |
Drosophila melanogaster |
| Insulin protease | - |
Rattus norvegicus |
| Insulin-degrading enzyme | - |
Homo sapiens |
| Insulin-degrading enzyme | - |
Rattus norvegicus |
| Insulinase | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
