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Literature summary for 3.4.24.56 extracted from
- Purification and characterization of insulin-degrading enzyme from pig skeletal muscle (1981), Endocrinology, 108, 1527-1532.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Proinsulin | competitive | Sus scrofa |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00007 | - |
Insulin | - |
Sus scrofa |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
x * 60000, pig, SDS-PAGE | Sus scrofa |
| 135000 | - |
pig, gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Glucagon + H2O | - |
Sus scrofa | Hydrolyzed glucagon | - |
? |  |
| Insulin + H2O | not: individual A and B-chains of insulin | Sus scrofa | Hydrolyzed insulin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 60000, pig, SDS-PAGE | Sus scrofa |
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