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Literature summary for 3.4.24.56 extracted from

  • Chowdhary, B.K.; Smith, G.D.; Peters, T.J.
    Subcellular localization and partial characterization of insulin proteolytic activity in rat liver (1985), Biochim. Biophys. Acta, 840, 180-186.
    View publication on PubMed
Search for more literature for 3.4.24.56

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus
Diamide
-
 Rattus norvegicus
Mg2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus
additional information not: leupeptin; not: pepstatin Rattus norvegicus
Zn2+ ZnCl2 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005 0.007 Insulin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
endoplasmic reticulum membrane-associated activity is highly latent Rattus norvegicus 5783
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus
Mg2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
300000
-
 rat, gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Insulin + H2O
-
 Rattus norvegicus Hydrolyzed insulin
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Rattus norvegicus