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Literature summary for 3.4.24.35 extracted from

  • Zaga-Clavellina, V.; Garcia-Lopez, G.; Flores-Pliego, A.; Merchant-Larios, H.; Vadillo-Ortega, F.
    In vitro secretion and activity profiles of matrix metalloproteinases, MMP-9 and MMP-2, in human term extra-placental membranes after exposure to Escherichia coli (2011), Reprod. Biol. Endocrinol., 9, 13.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.35

Activating Compound

Activating Compound Comment Organism Structure
4-aminophenylmercuric acetate artificial activation of the inactive zymogen Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TIMP-1
-
 Homo sapiens
TIMP-2
-
 Homo sapiens
TIMP-4
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
92000
-
 x * 92000 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the inactive zymogen is cleaved at the pro-peptide and activated to the mature MMP-9 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
amnion
-
 Homo sapiens
-
choriodecidua
-
 Homo sapiens
-
additional information levels of MMP-9 in choriodecidua and amnion increases 4 and 8fold, respectively, after simultaneous infection with Escherichia coli added to either the amniotic or the choriodecidual face or to both Homo sapiens
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 92000 Homo sapiens

Synonyms

Synonyms Comment Organism
MMP-9
-
 Homo sapiens
Type IV collagenase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens levels of MMP-9 in choriodecidua and amnion increases 4 and 8fold, respectively, after simultaneous infection with Escherichia coli added to either the amniotic or the choriodecidual face or to both up

General Information

General Information Comment Organism
malfunction infection of chorioamniotic membranes with Escherichia coli induces an increase in the secretion of inactive forms and an association to extracellular matrix of active forms of MMP-2 and MMP-9 without changes in inhibitor TIMP-1, -2, and -4.These changes explain the significant decrease of collagen content and loss of structural continuity Homo sapiens
physiological function MMP-9 has a role as essential mediator in degradation/damage of the extracellular matrix of fetal membranes Homo sapiens