Activating Compound | Comment | Organism | Structure |
---|---|---|---|
MMP-14 | MMP-14 activates MMP-2 during degeneration of invertebral disc, a major activation pathway of MMP-2 involves complex formation with MMP-14 and a tissue inhibitor of metalloproteinases-2, TIMP-2, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tissue inhibitor of metalloproteinases-2 | TIMP-2, complex formation with MMP-14 and MMP-2 activates the enzyme, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | main localization in invertebral disc, immunohistochemic analysis, overview | Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
x * 68000, active MMP-2, SDS-PAGE, x * 72000, proMMP-2, SDS-PAGE | Homo sapiens |
72000 | - |
x * 68000, active MMP-2, SDS-PAGE, x * 72000, proMMP-2, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | intervertebral disc degeneration is associated with the increased expression of several matrix metalloproteinases, in particular MMP-2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
annulus fibrosus | low content | Homo sapiens | - |
annulus fibrosus | endplate | Homo sapiens | - |
intervertebral disc | - |
Homo sapiens | - |
nucleus pulposus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | gelatin zymography | Homo sapiens | ? | - |
? | |
additional information | intervertebral disc degeneration is associated with the increased expression of several matrix metalloproteinases, in particular MMP-2, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 68000, active MMP-2, SDS-PAGE, x * 72000, proMMP-2, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MMP-2 | - |
Homo sapiens |