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Literature summary for 3.4.24.19 extracted from
- Procollagen C-endopeptidase (2004), Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 609-617.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Enhancer glycoprotein | stimulates activity | Homo sapiens | |
| TGFbeta | increases the expression of BMP-1 and Tld in human dermal fibroblasts | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | involved in deposition of collagen fibrils in the extracellular matrix following processing of procollagen propeptides, dorsoventral patterning through cleavage of chordin, collagen and elastin cross-linking by processing of inactive precursors of lysyl oxidases, proteoglycan maturation and assembly of the dermal-epidermal junction by processing of laminin 5 chains and cleaving the C-propeptide of type VII procollagen | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in baculovirus-infected Sf21 insect cells, HT-180 cells, 293-EBNA cells or COS-7 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | homozygous null mice lacking PCBs encoded by BMP-1 are perinatally lethal and have reduced ossification of skull bones and defects in formation of the ventral body wall, procollagen processing and collagen fibrillogenesis | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Homo sapiens |  |
| Ac-Met-Val-Gly-Asp-Asp-Pro-Tyr-Asn-NH2 | weak inhibitor | Homo sapiens | |
| acidic dipeptide hydroxamate derivates | mimic the location of aspartic acid residues in the P1' and P2' positions of the PCP cleavage site in procollagen | Homo sapiens | |
| alpha2-Macroglobulin | - |
Homo sapiens | |
| Arg | inhibits at 5-10 mM | Homo sapiens | |
| CdCl2 | - |
Homo sapiens | |
| concanavalin A | - |
Homo sapiens | |
| CuCl2 | inhibits at 0.01-0.1 mM | Homo sapiens | |
| di-/tripeptidic hydroxamic acid derivates | - |
Homo sapiens | |
| DTT | - |
Homo sapiens | |
| EDTA | - |
Homo sapiens | |
| EGTA | - |
Homo sapiens | |
| Lys | inhibits at 5-10 mM | Homo sapiens | |
| N-ethylmaleimide | inhibits at 20 mM | Homo sapiens | |
| NaCl | inhibits at 200-500 mM | Homo sapiens | |
| small molecule ox(adi)azolyl-hydroxamic acid derivates | - |
Homo sapiens | |
| sulfonamide hydrxamate derivates of ornithine analogs | - |
Homo sapiens | |
| Tris-HCl buffer | inhibits at 200-500 mM | Homo sapiens | |
| Tyr-Tyr-Arg-Ala-Asp-Asp-Ala | weak inhibitor | Homo sapiens | |
| ZnCl2 | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Strongylocentrotus purpuratus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required for activity | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 10700 | - |
immunoblotting, XBMP1-B in adults | Xenopus laevis |
| 63000 | - |
XBMP1-A in unfertilized eggs | Xenopus laevis |
| 71890 | - |
calculated | Strongylocentrotus purpuratus |
| 80000 | - |
SDS-PAGE, mature N-gycosylated enzyme | Mus musculus |
| 80670 | - |
XBMP1-B | Xenopus laevis |
| 82900 | - |
prepro-BMP1 | Homo sapiens |
| 100000 | - |
SDS-PAGE, mature N-gycosylated enzyme | Gallus gallus |
| 110200 | - |
XBMP1-A | Xenopus laevis |
| 111600 | - |
mTld | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Strongylocentrotus purpuratus | - |
- |
- |
| Xenopus laevis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
- |
Mus musculus |
| by anti-Flag affinity column | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adenocarcinoma cell | gastric epithelial adenocarcinoma stimulated with Helicobacter pylori | Homo sapiens | - |
| articular cartilage | - |
Homo sapiens | - |
| articular cartilage | - |
Rattus norvegicus | - |
| blastula | - |
Xenopus laevis | - |
| blood | tumor endothelial cells of malignant colorectal tissues | Homo sapiens | - |
| brain | mTld | Homo sapiens | - |
| chondrocyte | - |
Homo sapiens | - |
| chondrocyte | - |
Rattus norvegicus | - |
| dermis | - |
Homo sapiens | - |
| egg | - |
Xenopus laevis | - |
| embryo | - |
Xenopus laevis | - |
| embryo | in both ectodermal and primary mesenchyme cells in hatched blastula stage | Strongylocentrotus purpuratus | - |
| embryo | initially expressed at gastrulation stages, later during dorso-ventral patterning of the neural tube in neural crest and ventrally in the caudal notochord and floor plate, and during patterning of the somites | Gallus gallus | - |
| embryo | throughout the mesenchyme of developing embryonic tissue | Mus musculus | - |
| epiphysis | - |
Homo sapiens | - |
| epiphysis | - |
Rattus norvegicus | - |
| fibroblast | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| heart | mTld and BMP-1 | Homo sapiens | - |
| hindlimb | - |
Xenopus laevis | - |
| kidney | mTld and BMP-1 | Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | mTld and BMP-1 | Homo sapiens | - |
| lung | mTld and BMP-1 | Homo sapiens | - |
| MG-63 cell | - |
Homo sapiens | - |
| additional information | in developing membranous and endochondral bones, in sections of murine hind limp and femoral growth plate | Mus musculus | - |
| additional information | metaphysis | Homo sapiens | - |
| additional information | metaphysis | Rattus norvegicus | - |
| osteoblast | - |
Homo sapiens | - |
| osteoblast | - |
Rattus norvegicus | - |
| osteoclast | - |
Homo sapiens | - |
| osteoclast | - |
Rattus norvegicus | - |
| placenta | - |
Mus musculus | - |
| placenta | mTld and BMP-1 | Homo sapiens | - |
| skeletal muscle | mTld and BMP-1 | Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bovine lysyl oxidase-like precursor protein + H2O | cleaved at a Gly-Asp and Ser-Asp bond | Homo sapiens | ? | - |
? | |
| chordin + H2O | - |
Homo sapiens | ? | - |
? | |
| lamin 5 + H2O | gamma2 chain cleaved at a Gly-Asp bond, also cleavage of alpha3 chain | Homo sapiens | ? | - |
? | |
| pC-collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| pro-lysyl oxidase + H2O | cleaved at site Met-Val-Gyl-Asp-Asp-Pro | Homo sapiens | ? | - |
? | |
| probiglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| Procollagen type I + H2O | - |
Homo sapiens | Type I pNcollagen + C-propeptides | - |
? | |
| procollagen type II + H2O | - |
Homo sapiens | ? | - |
? | |
| procollagen type III + H2O | - |
Homo sapiens | ? | - |
? | |
| procollagen type VII + H2O | cleaved at an Ala-Asp bond | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BMP-1 | - |
Gallus gallus |
| BMP-1 | - |
Mus musculus |
| BMP-1 | - |
Homo sapiens |
| bone morphogenetic protein 1 | - |
Gallus gallus |
| bone morphogenetic protein 1 | - |
Mus musculus |
| bone morphogenetic protein 1 | - |
Homo sapiens |
| carboxy-terminal procollagen peptidase | - |
Gallus gallus |
| carboxy-terminal procollagen peptidase | - |
Mus musculus |
| carboxy-terminal procollagen peptidase | - |
Homo sapiens |
| carboxy-terminal procollagen peptidase | - |
Xenopus laevis |
| carboxy-terminal procollagen peptidase | - |
Strongylocentrotus purpuratus |
| carboxyl-procollagen peptidase | - |
Gallus gallus |
| carboxyl-procollagen peptidase | - |
Mus musculus |
| carboxyl-procollagen peptidase | - |
Homo sapiens |
| carboxyl-procollagen peptidase | - |
Xenopus laevis |
| carboxyl-procollagen peptidase | - |
Strongylocentrotus purpuratus |
| mammalian tolloid | - |
Mus musculus |
| mammalian tolloid | - |
Homo sapiens |
| MtlD | - |
Mus musculus |
| MtlD | - |
Homo sapiens |
| PCP | - |
Gallus gallus |
| PCP | - |
Mus musculus |
| PCP | - |
Homo sapiens |
| PCP | - |
Xenopus laevis |
| PCP | - |
Strongylocentrotus purpuratus |
| PCP-1 | - |
Gallus gallus |
| PCP-1 | - |
Mus musculus |
| PCP-1 | - |
Homo sapiens |
| PCP-2 | - |
Gallus gallus |
| PCP-2 | - |
Mus musculus |
| PCP-2 | - |
Homo sapiens |
| procollagen C-peptidase | - |
Gallus gallus |
| procollagen C-peptidase | - |
Mus musculus |
| procollagen C-peptidase | - |
Homo sapiens |
| procollagen C-peptidase | - |
Xenopus laevis |
| procollagen C-peptidase | - |
Strongylocentrotus purpuratus |
| Procollagen C-proteinase | - |
Gallus gallus |
| Procollagen C-proteinase | - |
Mus musculus |
| Procollagen C-proteinase | - |
Homo sapiens |
| Procollagen C-proteinase | - |
Rattus norvegicus |
| Procollagen C-proteinase | - |
Xenopus laevis |
| Procollagen C-proteinase | - |
Strongylocentrotus purpuratus |
| suBMP-1 | - |
Strongylocentrotus purpuratus |
| Tld | - |
Gallus gallus |
| tolloid | - |
Gallus gallus |
| XBMP1-A | - |
Xenopus laevis |
| XBMP1-B | - |
Xenopus laevis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.5 | - |
Homo sapiens |
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