Application | Comment | Organism |
---|---|---|
medicine | observation that napsin A is expressed in more than 90% of primary lung adenocarcinomas but not in other malignancies shows that napsin A might be a marker for this type of carcinoma. Potential use as a marker for kidney dysfunction | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
multivesicular body | - |
Homo sapiens | 5771 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39000 | - |
1 * 39000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pulmonary surfactant protein B + H2O | Homo sapiens | napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes | ? | - |
? | |
pulmonary surfactant protein C + H2O | Homo sapiens | napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | napsin A is expressed as preproenzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar cell type II | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung adenocarcinoma cell | primary, napsin A is expressed in more than 90% of primary lung adenocarcinomas but not in other malignancies | Homo sapiens | - |
spleen | - |
Homo sapiens | - |
urine | enzymatically active napsin A can be detected in urine of healthy individuals or in patients with transplanted kidney whose kidney function appears half to fully normal. Low activity in samples from patients with diseased kidneys | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pulmonary surfactant protein B + H2O | - |
Homo sapiens | ? | - |
? | |
pulmonary surfactant protein B + H2O | napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes | Homo sapiens | ? | - |
? | |
pulmonary surfactant protein C + H2O | - |
Homo sapiens | ? | - |
? | |
pulmonary surfactant protein C + H2O | napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 39000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
napsin A | - |
Homo sapiens |
TAO2 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | 5.5 | - |
Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5 | 6 | half-life more than 10 h | Homo sapiens |
7 | - |
half-life is around 4 h | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000002 | - |
pepstatin | - |
Homo sapiens |