Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.17 extracted from

  • Loh, Y.P.; Cawley, N.X.
    Yapsin A (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press, 1, 133-135.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates, dependent on the substrate Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
x * 68000 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-lipotropin + H2O Bos taurus
-
?
-
?
additional information Bos taurus the enzyme is highly specific for mono- and dibasic residues of prohormones, overview ?
-
?
pro-enkephalin + H2O Bos taurus
-
?
-
?
pro-insulin + H2O Bos taurus cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds insulin chain A + insulin chain B
-
?
pro-neuropeptide Y + H2O Bos taurus
-
?
-
?
pro-opiomelanocortin + H2O Bos taurus hormone activation opiomelanocortin + pro-sequence of opiomelanocortin
-
?
pro-vasopressin + H2O Bos taurus cleavage at a monobasic residue neurophysin + glycopeptide
-
?
pro-vasopressin + H2O Bos taurus cleavage of a Lys-Arg-/- bond vasopressin + pro-sequence of vasopressin
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Bos taurus

Purification (Commentary)

Purification (Comment) Organism
native enzyme from pituitary gland to homogeneity Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla chromaffin granules Bos taurus
-
pituitary gland intermediate lobe, anterior lobe, and neural lobe secretory granules Bos taurus
-

Storage Stability

Storage Stability Organism
-20°C, purified enzyme, 2-3 days stable Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-lipotropin + H2O
-
Bos taurus ?
-
?
additional information the enzyme is highly specific for mono- and dibasic residues of prohormones, overview Bos taurus ?
-
?
additional information the enzyme is highly specific for mono- and dibasic residues of prohormones Bos taurus ?
-
?
pro-enkephalin + H2O
-
Bos taurus ?
-
?
pro-insulin + H2O cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds Bos taurus insulin chain A + insulin chain B
-
?
pro-neuropeptide Y + H2O
-
Bos taurus ?
-
?
pro-opiomelanocortin + H2O
-
Bos taurus opiomelanocortin + pro-sequence of opiomelanocortin
-
?
pro-opiomelanocortin + H2O hormone activation Bos taurus opiomelanocortin + pro-sequence of opiomelanocortin
-
?
pro-vasopressin + H2O cleavage at a monobasic residue Bos taurus neurophysin + glycopeptide
-
?
pro-vasopressin + H2O cleavage of a Lys-Arg-/- bond Bos taurus vasopressin + pro-sequence of vasopressin
-
?

Subunits

Subunits Comment Organism
? x * 68000 Bos taurus
More immunogenic cross-reactive with anti-yapsin 1 antibodies due to high structural homology Bos taurus

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the peptidase family A1 Bos taurus
PCE
-
Bos taurus
yapsin A
-
Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4 5.5
-
Bos taurus

pI Value

Organism Comment pI Value Maximum pI Value
Bos taurus
-
4 3.5