Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin A | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Bos taurus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | stimulates, dependent on the substrate | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
x * 68000 | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-lipotropin + H2O | Bos taurus | - |
? | - |
? | |
additional information | Bos taurus | the enzyme is highly specific for mono- and dibasic residues of prohormones, overview | ? | - |
? | |
pro-enkephalin + H2O | Bos taurus | - |
? | - |
? | |
pro-insulin + H2O | Bos taurus | cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds | insulin chain A + insulin chain B | - |
? | |
pro-neuropeptide Y + H2O | Bos taurus | - |
? | - |
? | |
pro-opiomelanocortin + H2O | Bos taurus | hormone activation | opiomelanocortin + pro-sequence of opiomelanocortin | - |
? | |
pro-vasopressin + H2O | Bos taurus | cleavage at a monobasic residue | neurophysin + glycopeptide | - |
? | |
pro-vasopressin + H2O | Bos taurus | cleavage of a Lys-Arg-/- bond | vasopressin + pro-sequence of vasopressin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Bos taurus |
Purification (Comment) | Organism |
---|---|
native enzyme from pituitary gland to homogeneity | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | chromaffin granules | Bos taurus | - |
pituitary gland | intermediate lobe, anterior lobe, and neural lobe secretory granules | Bos taurus | - |
Storage Stability | Organism |
---|---|
-20°C, purified enzyme, 2-3 days stable | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-lipotropin + H2O | - |
Bos taurus | ? | - |
? | |
additional information | the enzyme is highly specific for mono- and dibasic residues of prohormones, overview | Bos taurus | ? | - |
? | |
additional information | the enzyme is highly specific for mono- and dibasic residues of prohormones | Bos taurus | ? | - |
? | |
pro-enkephalin + H2O | - |
Bos taurus | ? | - |
? | |
pro-insulin + H2O | cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds | Bos taurus | insulin chain A + insulin chain B | - |
? | |
pro-neuropeptide Y + H2O | - |
Bos taurus | ? | - |
? | |
pro-opiomelanocortin + H2O | - |
Bos taurus | opiomelanocortin + pro-sequence of opiomelanocortin | - |
? | |
pro-opiomelanocortin + H2O | hormone activation | Bos taurus | opiomelanocortin + pro-sequence of opiomelanocortin | - |
? | |
pro-vasopressin + H2O | cleavage at a monobasic residue | Bos taurus | neurophysin + glycopeptide | - |
? | |
pro-vasopressin + H2O | cleavage of a Lys-Arg-/- bond | Bos taurus | vasopressin + pro-sequence of vasopressin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 68000 | Bos taurus |
More | immunogenic cross-reactive with anti-yapsin 1 antibodies due to high structural homology | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the peptidase family A1 | Bos taurus |
PCE | - |
Bos taurus |
yapsin A | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | 5.5 | - |
Bos taurus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Bos taurus | - |
4 | 3.5 |