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Literature summary for 3.4.22.B61 extracted from
- Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens (2009), Vet. Parasitol., 160, 230-236.
Application
| Application | Comment | Organism |
|---|---|---|
| agriculture | vaccination of rats with recombinant zymogen and subsequent challenge with Fasciola hepatica metercercariae. Vaccination results in significantly smaller and fewer flukes than in controls. Maximal protection of 83% is seen in the group vaccinated with cathepsin B and cathepsin L5 in combinantion | Fasciola hepatica |
| medicine | cathepsin L5, cathepsin L1g and cathepsin B are expressed in yeast from cDNA clones isolated from adult, metacercariae and newly excysted juvenile flukes respectively. Each is used solely or in combination to vaccinate rats that are subsequently challenged with Fasciola hepatica metercercariae. Each protein induces an immune response, and all groups vaccinated with recombinant protein yield significantly fewer and smaller flukes than the control group. Maximal protection of 83% is seen in the group vaccinated with cathepsin B and cathepsin L5 in combination | Fasciola hepatica |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in yeast | Fasciola hepatica |
| expression of pro-form in yeast | Fasciola hepatica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Fasciola hepatica | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Fasciola hepatica |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adult | - |
Fasciola hepatica | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cat L5 | - |
Fasciola hepatica |
| cathepsin L5 | - |
Fasciola hepatica |
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Release 2023.1 (January 2023)
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