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Literature summary for 3.4.22.B6 extracted from

  • Mottram, J.C.; Coombs, G.H.; Alexander, J.
    Cysteine peptidases as virulence factors of Leishmania (2004), Curr. Opin. Microbiol., 7, 375-381.
    View publication on PubMed
Search for more literature for 3.4.22.B6

Inhibitors

Inhibitors Comment Organism Structure
CA074 specific inhibition of CPC Leishmania amazonensis
CA074 specific inhibition of CPC Leishmania major
CA074 specific inhibition of CPC Leishmania mexicana
cystatin protects against Leishmania infection in vivo Leishmania amazonensis
cystatin protects against Leishmania infection in vivo Leishmania mexicana
Leishmania cysteine peptidase inhibitor 1 i.e. ICP, inhibitor of CPs from family C1 clan A Leishmania amazonensis
Leishmania cysteine peptidase inhibitor 1 i.e. ICP, inhibitor of CPs from family C1 clan A Leishmania major
Leishmania cysteine peptidase inhibitor 1 i.e. ICP, inhibitor of CPs from family C1 clan A Leishmania mexicana

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Leishmania major 5764
-
vacuole
-
 Leishmania mexicana 5773
-
vacuole
-
 Leishmania amazonensis 5773
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania amazonensis the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole ?
-
 ?
additional information Leishmania major the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection ?
-
 ?
additional information Leishmania mexicana the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection, the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania amazonensis
-
-
-
Leishmania major
-
 gene CPC
-
Leishmania mexicana
-
 gene CPC
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote expression in virulence Leishmania mexicana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole Leishmania amazonensis ?
-
 ?
additional information the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection Leishmania major ?
-
 ?
additional information the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection, the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole Leishmania mexicana ?
-
 ?

Synonyms

Synonyms Comment Organism
CPC
-
 Leishmania mexicana
CPC
-
 Leishmania amazonensis
CPC
-
 Leishmania major
More the enzyme belongs to the cysteine protease family C1 clan CA Leishmania mexicana
More the enzyme belongs to the cysteine protease family C1 clan CA Leishmania amazonensis
More the enzyme belongs to the cysteine protease family C1 clan CA Leishmania major