Literature summary for 3.4.22.B5 extracted from

Santos, D.A.; de Souza Costa, M.G.; Alves, C.R.; Caffarena, E.R.
Structural and dynamic insights into the C-terminal extension of cysteine proteinase B from Leishmania amazonensis (2016), J. Mol. Graph. Model., 70, 30-39 .

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Organism

Organism	UniProt	Comment	Textmining
Leishmania amazonensis	-	-	-

General Information

General Information	Comment	Organism
physiological function	upon processing from its zymogen form, a release of the immunomodulatory CPB C-terminal extension (cyspep) into the cytoplasm of the macrophage takes place. Molecular models show a prevalence of beta-sheets in the cyspep protein. The formation of new strands, along with a rapid disruption of helical content, is observed	Leishmania amazonensis

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Release 2023.1 (January 2023)