Literature summary for 3.4.22.B5 extracted from

de Almeida, L.; Alves, K.F.; Maciel-Rezende, C.M.; Jesus, L.d.e. .O.; Pires, F.R.; Junior, C.V.; Izidoro, M.A.; Judice, W.A.; dos Santos, M.H.; Marques, M.J.
Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes (2015), Biomed. Pharmacother., 75, 93-99 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
[2-hydroxy-4-(2-methylpropoxy)phenyl](4-hydroxyphenyl)methanone	compound shows inhibitory activity against papain is a potent inhibitor of CPB2.8, CPB3.0 and cruzain, showing noncompetitive inhibition mechanism	Leishmania mexicana

Organism

Organism	UniProt	Comment	Textmining
Leishmania mexicana	P36400	isoform CPB2.8	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
amastigote	-	Leishmania mexicana	-

Synonyms

Synonyms	Comment	Organism
CPB2.8	-	Leishmania mexicana
CPB3.0	-	Leishmania mexicana

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0029	-	isoform CPB2.8, pH 5.5, 37°C	Leishmania mexicana	[2-hydroxy-4-(2-methylpropoxy)phenyl](4-hydroxyphenyl)methanone
0.0043	-	isoform CPB3.0, pH 5.5, 37°C	Leishmania mexicana	[2-hydroxy-4-(2-methylpropoxy)phenyl](4-hydroxyphenyl)methanone

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Release 2023.1 (January 2023)