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Literature summary for 3.4.22.B5 extracted from

  • Cameron, P.; McGachy, A.; Anderson, M.; Paul, A.; Coombs, G.H.; Mottram, J.C.; Alexander, J.; Plevin, R.
    Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway (2004), J. Immunol., 173, 3297-3304.
    View publication on PubMed
Search for more literature for 3.4.22.B5

Application

Application Comment Organism
medicine amastigote-specific cysteine peptidases of Leishmania mexicana are central to the ability of the parasite to modulate signaling vie NF-kapaB and consequently inhibit IL-12 production by mouse bone marrow-derived macrophages Leishmania mexicana

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Leishmania mexicana

Inhibitors

Inhibitors Comment Organism Structure
cathepsin L inhibitor IV
-
 Leishmania mexicana
E64
-
 Leishmania mexicana
K11002
-
 Leishmania mexicana

Organism

Organism UniProt Comment Textmining
Leishmania mexicana
-
-
-
Leishmania mexicana MYNC/BZ/62/M379
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Leishmania mexicana

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania mexicana
-

Storage Stability

Storage Stability Organism
-20°C Leishmania mexicana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GST-IkappaBalpha + H2O degradation by CPB2.8 Leishmania mexicana ?
-
 ?
GST-IkappaBalpha + H2O degradation by CPB2.8 Leishmania mexicana MYNC/BZ/62/M379 ?
-
 ?

Synonyms

Synonyms Comment Organism
CPB
-
 Leishmania mexicana
CPB2.8
-
 Leishmania mexicana
cysteine peptidase B
-
 Leishmania mexicana