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Literature summary for 3.4.22.B26 extracted from

  • Marion, A.; Dieudonne, F.X.; Patino-Garcia, A.; Lecanda, F.; Marie, P.J.; Modrowski, D.
    Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma (2011), Int. J. Cancer, 130, 2514-2525.
    View publication on PubMed
Search for more literature for 3.4.22.B26

Application

Application Comment Organism
medicine calpain-6 is a therapeutic target in chemoresistant osteosarcoma Homo sapiens
medicine calpain-6 is a possible therapeutic target in chemoresistant osteosarcoma Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
143B cell
-
 Homo sapiens
-
bone
-
 Homo sapiens
-
bone marrow
-
 Homo sapiens
-
MG-63 cell
-
 Homo sapiens
-
MNNG/HOS cell
-
 Homo sapiens
-
osteosarcoma cell
-
 Homo sapiens
-
SAOS-2 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
calpain-6
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens calpain-6 is a target gene downregulated by syndecan-2 in cells and in vivo. Syndecan-2 decreases calpain-6 expression by inhibiting endothelin-1-induced signaling down
Homo sapiens calpain-6 expression in osteosarcoma cells depends on endothelin-1. Calpain-6 is increased by doxorubicin (10 ng/ml) and expressed at higher levels in doxorubicin-resistant U2OS osteosarcoma-derived cells as compared to responsive cells up
Homo sapiens calpain-6 expression depends on NFkappaB activity and endothelin-1. Calpain-6 expression is increased by doxorubicin up

General Information

General Information Comment Organism
malfunction inhibition of calpain-6 with shRNA results in decreased proliferation, increased spontaneous apoptosis and increased sensitivity to doxorubicin and also methotrexate in responsive and resistant osteosarcoma cells Homo sapiens
metabolism the enzyme capain-6 is negatively controlled by the proteoglycan syndecan-2, that controls the activity of various cytokines and growth factors and also modulates apoptosis and response to cytotoxic agents in osteosarcoma cell lines. Syndecan-2 exerts its pro-apoptotic function through modulation of the endothelin-1/NFkappaB signaling and through downregulation of calpain-6. Calpain-6 expression in osteosarcoma cells depends on endothelin-1, a mediator of the tumor progression in bone. Syndecan-2 overexpression alters ERK1/2, PI3K/AKT and NFjB pathways that are calpain-6-promoting signals downstream of endothelin-1 Homo sapiens
physiological function calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma Homo sapiens
physiological function calpain-6 is a protective factor that contributes to abnormal cell survival Homo sapiens