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Literature summary for 3.4.22.65 extracted from

  • Reddy, V.B.; Lerner, E.A.
    Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation (2017), J. Biol. Chem., 292, 17399-17406 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mas-related G-protein-coupled receptor C11 + H2O Dermatophagoides farinae mouse protein ?
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 ?
mas-related G-protein-coupled receptor X1 + H2O Dermatophagoides farinae human protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dermatophagoides farinae P16311
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mas-related G-protein-coupled receptor C11 + H2O human protein Dermatophagoides farinae ?
-
 ?
mas-related G-protein-coupled receptor C11 + H2O mouse protein Dermatophagoides farinae ?
-
 ?
mas-related G-protein-coupled receptor X1 + H2O human protein Dermatophagoides farinae ?
-
 ?

Synonyms

Synonyms Comment Organism
Der p1
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 Dermatophagoides farinae

General Information

General Information Comment Organism
physiological function Der p1 activates the human receptor mas-related G-protein-coupled receptor X1 and the mouse homolog mas-related G-protein-coupled receptor C11. Der p1 also induces the release of IL-6 from heterologous cells expressing mas-related G-protein-coupled receptor X1 Dermatophagoides farinae