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Literature summary for 3.4.22.63 extracted from

  • Chen, H.; Xia, Y.; Fang, D.; Hawke, D.; Lu, Z.
    Caspase-10-mediated heat shock protein 90beta cleavage promotes UVB irradiation-induced cell apoptosis (2009), Mol. Cell. Biol., 29, 3657-3664.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
caspase-8 caspase-8 cleaves and activates caspase-10 directly Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in NIH-3T3 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-AEVD-fluoromethylketone caspase-10 inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hsp90beta + H2O Hsp90beta is cleaved by activated caspase-10 under UV-B irradiation at D278, P293, and D294 Homo sapiens ?
-
 ?