Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.61 extracted from

  • Chattopadhyay, R.; Bhattacharyya, A.; Crowe, S.E.
    Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection (2010), Cancer Res., 70, 2799-2808.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-IETD-fluoromethylketone
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18000
-
cleaved caspase-8, SDS-PAGE Homo sapiens
43000
-
procaspase-8 shows two bands at 57000 and 43000 Da, SDS-PAGE Homo sapiens
57000
-
procaspase-8 shows two bands at 57000 and 43000 Da, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
Homo sapiens
-
gastric adenocarcinoma cell
-
Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens there is an increase in active caspase-8 within 4 h of Helicobacter pylori infection in APE-1-downregulated cells relative to the control cells up

General Information

General Information Comment Organism
physiological function programmed cell death involves the caspase-8-dependent extrinsic pathway Homo sapiens