Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amyloid beta | treatment of rat hippocampal neuron extracts with either 300 nM or 0.001 mM amyloid beta leads to activation of caspase-2 | Rattus norvegicus | |
VDVAD | - |
Mus musculus | |
VDVAD | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P29594 | - |
- |
Rattus norvegicus | P55215 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Mus musculus | - |
hippocampus | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
Casp2 | - |
Mus musculus |
Casp2 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | down-regulation or inactivation of caspase-2 blocks amyloid beta-mediated effects on primary hippocampal cultures | Mus musculus |
malfunction | down-regulation or inactivation of caspase-2 blocks amyloid beta-mediated effects on primary hippocampal cultures | Rattus norvegicus |
metabolism | caspase-2 is a critical mediator in the activation of the RhoA/ROCK-II signaling pathway, leading to the collapse of dendritic spines. Inactive RhoA-GDP but not active RhoA-GTP forms a complex with caspase-2 | Mus musculus |
metabolism | caspase-2 is a critical mediator in the activation of the RhoA/ROCK-II signaling pathway, leading to the collapse of dendritic spines. Inactive RhoA-GDP but not active RhoA-GTP forms a complex with caspase-2 | Rattus norvegicus |
physiological function | caspase-2 plays a critical role in mediating the synaptic changes and memory alteration induced by amyloid beta in Alzheimer's disease | Mus musculus |
physiological function | caspase-2 plays a critical role in mediating the synaptic changes and memory alteration induced by amyloid beta in Alzheimer's disease | Rattus norvegicus |