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Literature summary for 3.4.22.27 extracted from

  • Wang, B.; Sun, J.; Kitamoto, S.; Yang, M.; Grubb, A.; Chapman, H.A.; Kalluri, R.; Shi, G.P.
    Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors (2006), J. Biol. Chem., 281, 6020-6029.
    View publication on PubMed
Search for more literature for 3.4.22.27

Cloned(Commentary)

Cloned (Comment) Organism
expression of Cat S Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of Cat S-deficient mutant mice, the mutant mice demonstrate impaired angiogenesis and tumor cell proliferation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cystatin C endogenous specific enzyme inhibitor, absence of cystatin C results in increased angiogene sis and tumor cell proliferation Homo sapiens
cystatin C endogenous specific enzyme inhibitor, absence of cystatin C results in increased angiogenesis and tumor cell proliferation Mus musculus
N-morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl specific inhibitor Homo sapiens
N-morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl specific inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
laminin-5 + H2O Mus musculus degradation laminin-5 gamma-2 fragments
-
 ?
laminin-5 + H2O Homo sapiens degradation laminin-5 gamma-2 fragments
-
 ?
laminin-5 + H2O Mus musculus C57BL/6 degradation laminin-5 gamma-2 fragments
-
 ?
additional information Mus musculus cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview ?
-
 ?
additional information Homo sapiens cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview ?
-
 ?
additional information Mus musculus C57BL/6 cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 C57/BL6 mice
-
Mus musculus C57BL/6
-
 C57/BL6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell epidermal carcinoma cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arresten + H2O degradation, recombinant enzyme Homo sapiens ?
-
 ?
canstatin + H2O degradation, recombinant enzyme Homo sapiens ?
-
 ?
laminin-5 + H2O degradation Mus musculus laminin-5 gamma-2 fragments
-
 ?
laminin-5 + H2O degradation Homo sapiens laminin-5 gamma-2 fragments
-
 ?
laminin-5 + H2O degradation Homo sapiens laminin-5 gamma-2 fragments bioactive gamma2-fragments of 100 kDa, 80 kDa, and 50 kDa ?
laminin-5 + H2O degradation Mus musculus C57BL/6 laminin-5 gamma-2 fragments
-
 ?
additional information cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview Mus musculus ?
-
 ?
additional information cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview Homo sapiens ?
-
 ?
additional information cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
Cat S
-
 Mus musculus
Cat S
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Mus musculus
5.5
-
 assay at Homo sapiens