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Literature summary for 3.4.22.16 extracted from

  • Lu, W.D.; Funkelstein, L.; Toneff, T.; Reinheckel, T.; Peters, C.; Hook, V.
    Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters (2012), J. Neurochem., 122, 512-522.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information amastatin, arphamenine A, and bestatin have no effect on cathepsin H Bos taurus
additional information amastatin, arphamenine A, and bestatin have no effect on cathepsin H Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory vesicle
-
Mus musculus 99503
-
secretory vesicle
-
Bos taurus 99503
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
x * 28000, SDS-PAGE Mus musculus
28000
-
x * 28000, SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
Bos taurus
-
brain
-
Mus musculus
-
chromaffin cell
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg-7-amido-4-methylcoumarin + H2O best substrate Mus musculus L-Arg + 7-amino-4-methylcoumarin
-
?
L-Arg-7-amido-4-methylcoumarin + H2O best substrate Bos taurus L-Arg + 7-amino-4-methylcoumarin
-
?
L-Lys-7-amido-4-methylcoumarin + H2O best substrate Mus musculus L-Lys + 7-amino-4-methylcoumarin
-
?
L-Lys-7-amido-4-methylcoumarin + H2O best substrate Bos taurus L-Lys + 7-amino-4-methylcoumarin
-
?
Lys-Arg-(Met)enkephalin + H2O
-
Mus musculus Lys-Arg + (Met)enkephalin
-
?
Lys-Arg-(Met)enkephalin + H2O
-
Bos taurus Lys-Arg + (Met)enkephalin
-
?
Lys-Lys-(Met)enkephalin + H2O
-
Mus musculus Lys-Lys + (Met)enkephalin
-
?
Lys-Lys-(Met)enkephalin + H2O
-
Bos taurus Lys-Lys + (Met)enkephalin
-
?

Subunits

Subunits Comment Organism
? x * 28000, SDS-PAGE Mus musculus
? x * 28000, SDS-PAGE Bos taurus

General Information

General Information Comment Organism
malfunction knockout of the cathepsin H gene results in 50% reduction of (Met)enkephalin in mouse brain. Cathepsin H deficient mice also show a substantial 80% decrease in galanin peptide neurotransmitter levels in brain Mus musculus
physiological function cathepsin H plays a role in enkephalin and galanin peptide neurotransmitter production Mus musculus
physiological function cathepsin H plays a role in enkephalin and galanin peptide neurotransmitter production Bos taurus