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Literature summary for 3.4.22.15 extracted from

  • Legowska, M.; Wysocka, M.; Burster, T.; Pikula, M.; Rolka, K.; Lesner, A.
    Ultrasensitive internally quenched substrates of human cathepsin L (2014), Anal. Biochem., 466, 30-37.
    View publication on PubMed
Search for more literature for 3.4.22.15

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00027
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Ser-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens
0.00104
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Gln-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens
0.00153
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Ala-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-3-biphenyl-L-Ala-Arg-Ala-Ala-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens Abz-3-biphenyl-L-Ala-Arg + L-Ala-Ala-3-nitrotyrosineamide
-
 ?
Abz-3-biphenyl-L-Ala-Arg-Ala-Gln-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens Abz-3-biphenyl-L-Ala-Arg + L-Ala-Gln-3-nitrotyrosineamide
-
 ?
Abz-3-biphenyl-L-Ala-Arg-Ala-Ser-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens Abz-3-biphenyl-L-Ala-Arg + L-Ala-Ser-3-nitrotyrosineamide
-
 ?

Synonyms

Synonyms Comment Organism
cat L
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.01
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Ser-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens
17.4
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Ala-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens
27
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Gln-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
11400
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Ala-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens
18600
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Ser-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens
26000
-
 Abz-3-biphenyl-L-Ala-Arg-Ala-Gln-Tyr(3-NO2)-NH2 in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C Homo sapiens